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330 results on '"Harman A"'

2. The top 10 research priorities for the treatment of bullous pemphigoid, mucous membrane pemphigoid and pemphigus vulgaris in the UK: results of a James Lind Alliance Priority Setting Partnership

Author

Harman, Karen E, primary, Barha, Jag, additional, Chalmers, Jo R, additional, Dart, John K G, additional, Davies, Isobel, additional, Ellis, Patricia, additional, Grindlay, Douglas, additional, Hampton, Philip J, additional, Hill, Sharleen, additional, Hockey, Sharon, additional, Lloyd-Lavery, Antonia, additional, McPhee, Maggie, additional, Murphy, Ruth, additional, Rauz, Saaeha, additional, Setterfield, Jane F, additional, Thompson, Ingrid, additional, Westmoreland, Melanie, additional, and Waistell, Christina, additional

Published
2023
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3. The top 10 research priorities for the treatment of bullous pemphigoid, mucous membrane pemphigoid and pemphigus vulgaris in the UK: results of a James Lind Alliance Priority Setting Partnership

Author

Karen E Harman, Jag Barha, Jo R Chalmers, John K G Dart, Isobel Davies, Patricia Ellis, Douglas Grindlay, Philip J Hampton, Sharleen Hill, Sharon Hockey, Antonia Lloyd-Lavery, Maggie McPhee, Ruth Murphy, Saaeha Rauz, Jane F Setterfield, Ingrid Thompson, Melanie Westmoreland, and Christina Waistell

Subjects
Dermatology
Abstract

To identify priorities for future research into the treatment of bullous pemphigoid, mucous membrane pemphigoid and pemphigus vulgaris, we conducted a Priority Setting Partnership using James Lind Alliance methodology. The top 10 priorities identified in this PSP represent the key questions that patients, carers and healthcare professionals have about the treatment of these diseases and which future research will hopefully address.

Published
2023
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21. The global incidence of bullous pemphigoid: a systematic review and meta‐analysis.

Author

Persson, M.S.M., Begum, N., Grainge, M.J., Harman, K.E., Grindlay, D., and Gran, S.

Subjects
BULLOUS pemphigoid, AUTOIMMUNE diseases, OLDER people, AGE groups, GREY literature, CONFIDENCE intervals
Abstract

Summary: Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study aim is to pool the global incidence of BP and determine whether this varies according to geographic area, age group, setting and study quality. Methods: Ovid MEDLINE, Ovid Embase and grey literature were systematically searched on 7 April 2020. Two reviewers independently screened, extracted data and appraised each study's quality using the Joanna Briggs Institute critical appraisal tool. Two domains, indicative of selection and survey bias, were used to identify high‐quality studies. The cumulative incidence was standardized to 1 year and pooled in a random‐effects meta‐analysis. Subgroup and sensitivity analyses were conducted. Results: Twenty‐seven studies were identified, of which 23 provided cumulative incidence and four provided incidence rates. The cumulative incidence of BP was 8·2 [95% confidence interval (CI) 4·8–13.7] per million people whereas the incidence rate was 34·2 (95% CI 19·2–60·7) per million person‐years. Of the continents that contributed more than one study, the cumulative incidence was 10·3 (95% CI 5·8–18·2) and 5·6 (95% CI 3·5–9·0) per million people in Europe and Asia, respectively. The incidence was highest in studies including adults only (n = 2), in population‐based studies (n = 9) and in more recent years. The cumulative incidence was higher (13·3 per million people, 95% CI 6·0–29·5) when restricting the analysis to higher‐quality studies (n = 11). High heterogeneity (I2 > 82%) was observed across all pooled estimates. Conclusions: The incidence of BP varies globally, is generally low but appears to be increasing over time. The burden of disease is likely to be underestimated. Whatis already known about this topic?Bullous pemphigoid (BP) is a disease of older people.BP is associated with considerable mortality and comorbidity. Whatdoes this study add?The incidence of BP varies globally, is highest in North America and Europe, and appears to be increasing over time.The burden of disease is likely to be underestimated due to the considerable selection bias and incomplete capture of cases.Great attention needs to be paid to the design of future studies to ensure complete capture of cases within the population at risk. Linked Comment: V. Aoki and D. Miyamoto. Br J Dermatol 2022; 186:386–387. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Paraneoplastic cicatricial pemphigoid

Author

SETTERFIELD, J., SHIRLAW, P. J., LAZAROVA, Z., BRYANT, B. M., BHOGAL, B. S., HARMAN, K., CHALLACOMBE, S. J., and BLACK, M. M.

Published
1999

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