1. Association of <scp>IRF</scp> 4 single‐nucleotide polymorphism rs12203592 with melanoma‐specific survival
- Author
-
Anne E. Cust, Sarah V. Ward, David C. Gibbs, Colin B. Begg, Stefano Rosso, P.A. Kanetsky, Li Luo, Nancy E. Thomas, Hoda Anton-Culver, Marianne Berwick, Irene Orlow, Terence Dwyer, Richard P. Gallagher, R. Zanetti, and Stephen B. Gruber
- Subjects
Genetics ,Skin Neoplasms ,Genotype ,Single-nucleotide polymorphism ,Melanoma specific survival ,Dermatology ,Biology ,Polymorphism, Single Nucleotide ,Article ,Survival Rate ,Interferon Regulatory Factors ,Humans ,Genetic Predisposition to Disease ,Melanoma ,IRF4 - Abstract
We have previously shown that the functional melanoma risk variant rs12203592 in interferon regulatory factor-4 (IRF4) was associated with increased Breslow thickness, an important prognostic indicator for melanoma. In line with this, a recent study found evidence for an association between the minor T allele of this single nucleotide polymorphism (SNP) and melanoma-specific survival in patients from two European hospitals.
- Published
- 2020
- Full Text
- View/download PDF