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The sebum excretion rate and chemical composition of sebum from the foreheads of 4 young men with acne vulgaris were changed markedly when a 2-naphthol paste was applied to other skin sites. The excretion rate, free Fatty acid content and wax ester content fell but the triglyceride content increased. Recurrence of acne on stopping treatment was associated with an increase in wax ester content and a decrease in triglyceride content but little change in excretion rate and free fatty acid content. [ABSTRACT FROM AUTHOR]

The sebum excretion rate, sebaceous count and the chemical composition of the sebum have been determined in 10 young men without or with minimal acne vulgaris and 20 young men with gross acne vulgaris. No significant relation between the sebum excretion rate and the presence of acne was found. Significant differences were found in the triglyceride and the aliphatic alcohol wax ester contents of sebum from the 2 groups. The results are discussed in relation to current ideas on the pathogenesis of acne. [ABSTRACT FROM AUTHOR]

A man aged 22, exposed to 9-bromofluorene developed an extensive bullous eruption. A patch test with pure 9-bromofluorene in a healthy subject not previously exposed to this substance provoked a mild and transient reaction at 24 hr., but a severe reaction 9-10 days later. The delayed reaction was characterized histologically by intense epidermal hyperplasia, pseudoepitheliomatous in degree, and a dense cellular infiltrate in the upper dermis, These effects are discussed in relation to the reactions normally obtained in contact hypersensitivity. [ABSTRACT FROM AUTHOR]

Samples of sebum from 6 young men with acne vulgaris were analysed before and after systemic treatment with tetracycline for 4 and for 8 weeks. The rate of sebum production was not significantly changed. At 4 weeks there was a consistent fall in the free fatty acids and a slight rise in the triglycerides. After 8 weeks there was a marked fall in the aliphatic alcohol ester fraction. [ABSTRACT FROM AUTHOR]

A method is reported for the qualitative and quantitative analysis of less than milligram quantities of sebum into its lipid components using thin-layer absorption chromatography. The procedure has been developed to study relatively large numbers of samples, such as are collected from subjects taking part in a clinical therapeutic trial. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor about the treatment of Kyrle's disease.