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Your search keyword '"Faraci, Maura"' showing total 5 results
Start Over Author "Faraci, Maura" Journal british journal of haematology
5 results on '"Faraci, Maura"'

1. Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the I‐BFM Study Group

Author

Pichler, Herbert, primary, Sedlacek, Petr, additional, Meisel, Roland, additional, Beier, Rita, additional, Faraci, Maura, additional, Kalwak, Krzysztof, additional, Ifversen, Marianne, additional, Müller, Ingo, additional, Stein, Jerry, additional, Vettenranta, Kim, additional, Kropshofer, Gabriele, additional, Kolenova, Alexandra, additional, Karlhuber, Susanne, additional, Glogova, Evgenia, additional, Poetschger, Ulrike, additional, Peters, Christina, additional, Suttorp, Meinolf, additional, Matthes‐Leodolter, Susanne, additional, and Balduzzi, Adriana, additional

Published
2024
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3. Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation

Author

MESSINA, CHIARA, LOCATELLI, FRANCO, LANINO, EDOARDO, UDERZO, CORNELIO, ZACCHELLO, GRAZIELLA, CESARO, SIMONE, PILLON, MARTA, PEROTTI, CESARE, DEL FANTE, CLAUDIA, FARACI, MAURA, RIVABELLA, LUCIA, CALORE, ELISABETTA, DE STEFANO, PIETRO, ZECCA, MARCO, GIORGIANI, GIOVANNA, BRUGIOLO, ALESSANDRA, BALDUZZI, ADRIANA, DINI, GIORGIO, ZANESCO, LUIGI, and DALLʼAMICO, ROBERTO

Published
2003

4. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita

Author

Fioredda, Francesca, primary, Iacobelli, Simona, additional, Korthof, Elisabeth T., additional, Knol, Cora, additional, van Biezen, Anja, additional, Bresters, Dorine, additional, Veys, Paul, additional, Yoshimi, Ayami, additional, Fagioli, Franca, additional, Mats, Brune, additional, Zecca, Marco, additional, Faraci, Maura, additional, Miano, Maurizio, additional, Arcuri, Luca, additional, Maschan, Michael, additional, O'Brien, Tracey, additional, Diaz, Miguel A., additional, Sevilla, Julian, additional, Smith, Owen, additional, Peffault de Latour, Regis, additional, de la Fuente, Josue, additional, Or, Reuven, additional, Van Lint, Maria T., additional, Tolar, Jakub, additional, Aljurf, Mahmoud, additional, Fisher, Alain, additional, Skorobogatova, Elena V., additional, Diaz de Heredia, Cristina, additional, Risitano, Antonio, additional, Dalle, Jean-Hugues, additional, Sedláček, Petr, additional, Ghavamzadeh, Ardeshir, additional, and Dufour, Carlo, additional

Published
2018
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5. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita

Author

Julián Sevilla, Paul Veys, E T Korthof, Régis Peffault de Latour, Dorine Bresters, Tracey A. O'Brien, Marco Zecca, Maura Faraci, Simona Iacobelli, Jean Hugues Dalle, Antonio M. Risitano, Luca Arcuri, Maurizio Miano, Francesca Fioredda, Ardeshir Ghavamzadeh, Reuven Or, Miguel Angel Diaz, Brune Mats, E V Skorobogatova, Josue de la Fuente, Cora Knol, Petr Sedlacek, Franca Fagioli, Cristina Díaz de Heredia, Ayami Yoshimi, Michael Maschan, Jakub Tolar, Owen P. Smith, Carlo Dufour, Mahmoud Aljurf, Maria Teresa Van Lint, Alain Fisher, Anja van Biezen, Fioredda, Francesca, Iacobelli, Simona, Korthof, Elisabeth T., Knol, Cora, van Biezen, Anja, Bresters, Dorine, Veys, Paul, Yoshimi, Ayami, Fagioli, Franca, Mats, Brune, Zecca, Marco, Faraci, Maura, Miano, Maurizio, Arcuri, Luca, Maschan, Michael, O'Brien, Tracey, Diaz, Miguel A., Sevilla, Julian, Smith, Owen, Peffault de Latour, Regi, de la Fuente, Josue, Or, Reuven, Van Lint, Maria T., Tolar, Jakub, Aljurf, Mahmoud, Fisher, Alain, Skorobogatova, Elena V., Diaz de Heredia, Cristina, Risitano, Antonio, Dalle, Jean-Hugue, Sedláček, Petr, Ghavamzadeh, Ardeshir, and Dufour, Carlo

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Transplantation Conditioning, Pulmonary Fibrosis, haematopoietic stem cell transplantation, Graft vs Host Disease, Disease, dyskeratosis congenita, Settore MED/01 - Statistica Medica, Young Adult, bone marrow failure, Hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Bone Marrow Diseases, business.industry, Age Factors, Hematopoietic Stem Cell Transplantation, Bone marrow failure, medicine.disease, Survival Analysis, Tissue Donors, Transplantation, Haematopoiesis, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Bone marrow, Stem cell, business, Dyskeratosis congenita, 030215 immunology
Abstract

Dyskeratosis congenita (DC) is a genetic multisystem disorder with frequent involvement of the bone marrow. Haematopoietic stem cell transplantation (HSCT) is the only definitive cure to restore haematopoiesis, even though it cannot correct other organ dysfunctions. We collected data on the outcome of HSCT in the largest cohort of DC (n = 94) patients ever studied. Overall survival (OS) and event-free survival (EFS) at 3 years after HSCT were 66% and 62%, respectively. Multivariate analysis showed better outcomes in patients aged less than 20 years and in patients transplanted from a matched, rather than a mismatched, donor. OS and EFS curves tended to decline over time. Early lethal events were infections, whereas organ damage and secondary malignancies appeared afterwards, even a decade after HSCT. A non-myeloablative conditioning regimen appeared to be most advisable. Organ impairment present before HSCT seemed to favour the development of chronic graft-versus-host disease and T-B immune deficiency appeared to enhance pulmonary fibrosis. According to the present data, HSCT in DC is indicated in cases of progressive marrow failure, whereas in patients with pre-existing organ damage, this should be carefully evaluated. Further efforts to investigate treatment alternatives to HSCT should be encouraged.

Published
2018

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