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Your search keyword '"Giansily‐Blaizot, Muriel"' showing total 5 results
Start Over Author "Giansily‐Blaizot, Muriel" Journal british journal of haematology
5 results on '"Giansily‐Blaizot, Muriel"'

5. Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding.

Author

Giansily-Blaizot M, Biron-Andreani C, Aguilar-Martinez P, de Moeloose P, Briquel ME, Goudemand J, Stieltjes N, Barrot C, Chambost H, Durin A, Gay V, Peynet J, Pouymayou K, and Schved JF

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Blood Transfusion, Child, Female, Genetic Predisposition to Disease, Hemostasis, Surgical, Humans, Male, Middle Aged, Patient Selection, Pregnancy, Retrospective Studies, Risk Factors, Blood Loss, Surgical, Factor VII Deficiency surgery, Hemorrhage genetics
Abstract

Inherited factor VII (FVII) deficiency is a rare autosomal disorder characterized by a weak relationship between FVII activity (FVII:C) and operative bleeding risk. We report a retrospective study of 17 patients with a FVII:C below 0.1 IU/ml, in whom surgery was performed without any replacement therapy. Clinical and biological data were analysed to establish predictive criteria for bleeding tendency. We found that systematic preoperative replacement therapy may not be necessary for 'minor' surgical procedures, for patients suffering from inherited FVII deficiency, unless the clinical history includes severe haemorrhagic symptoms such as haemarthrosis, severe haematomas (even of soft tissue) or abundant epistaxis.

Published
2002
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