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Your search keyword '"Iacobelli, Simona"' showing total 9 results
Start Over Author "Iacobelli, Simona" Journal british journal of haematology
9 results on '"Iacobelli, Simona"'

1. Allogeneic hematopoietic cell transplantation in patients with myelodysplastic syndrome using treosulfan based compared to other reduced‐intensity or myeloablative conditioning regimens. A report of the chronic malignancies working party of the EBMT

Author

Shimoni, Avichai, primary, Robin, Marie, additional, Iacobelli, Simona, additional, Beelen, Dietrich, additional, Mufti, Ghulam J., additional, Ciceri, Fabio, additional, Bethge, Wolfgang, additional, Volin, Liisa, additional, Blaise, Didier, additional, Ganser, Arnold, additional, Luft, Thomas, additional, Chevallier, Patrice, additional, Schwerdtfeger, Rainer, additional, Koster, Linda, additional, de Witte, Theo, additional, Kröger, Nicolaus, additional, Nagler, Arnon, additional, and Yakoub-Agha, Ibrahim, additional

Published
2021
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2. Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT

Author

McLornan, Donal P., primary, Malpassuti, Vittoria, additional, Lippinkhof‐Kozijn, Anne, additional, Potter, Victoria, additional, Beelen, Dietrich, additional, Bunjes, Donald, additional, Sengeloev, Henrik, additional, Radujkovic, Aleksandar, additional, Passweg, Jakob, additional, Chalandon, Yves, additional, Kröger, Nicolaus, additional, Wulf, Gerald G., additional, Johansson, Jan‐Erik, additional, Ciceri, Fabio, additional, Bornhäuser, Martin, additional, Holler, Ernst, additional, Guffroy, Blandine, additional, Martin, Sonja, additional, Neubauer, Andreas, additional, Gramatski, Martin, additional, Robin, Marie, additional, Iacobelli, Simona, additional, Hayden, Patrick, additional, Hernández Boluda, Juan C., additional, Czerw, Tomasz, additional, and Yakoub‐Agha, Ibrahim, additional

Published
2020
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3. Liposomal daunorubicin versus standard daunorubicin: long term follow-up of the GIMEMA GSI 103 AMLE randomized trial in patients older than 60 years with acute myelogenous leukaemia

Author

Latagliata, Roberto, Breccia, Massimo, Fazi, Paola, Iacobelli, Simona, Martinelli, Giovanni, Di Raimondo, Francesco, Sborgia, Marco, Fabbiano, Francesco, Pirrotta, Maria Teresa, Zaccaria, Alfonso, Amadori, Sergio, Caramatti, Cecilia, Falzetti, Franca, Candoni, Anna, Mattei, Daniele, Morselli, Monica, Alimena, Giuliana, Vignetti, Marco, Baccarani, Michele, and Mandelli, Franco

Published
2008

4. Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma

Author

Kröger, Nicolaus, Shaw, Bronwen, Iacobelli, Simona, Zabelina, Tatjana, Peggs, Karl, Shimoni, Avichai, Nagler, Arnon, Binder, Thomas, Eiermann, Thomas, Madrigal, Alejandro, Schwerdtfeger, Rainer, Kiehl, Michael, Sayer, Herbert Gottfried, Beyer, Jörg, Bornhäuser, Martin, Ayuk, Francis, Zander, Axel Rolf, and Marks, David I.

Published
2005

5. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita

Author

Fioredda, Francesca, primary, Iacobelli, Simona, additional, Korthof, Elisabeth T., additional, Knol, Cora, additional, van Biezen, Anja, additional, Bresters, Dorine, additional, Veys, Paul, additional, Yoshimi, Ayami, additional, Fagioli, Franca, additional, Mats, Brune, additional, Zecca, Marco, additional, Faraci, Maura, additional, Miano, Maurizio, additional, Arcuri, Luca, additional, Maschan, Michael, additional, O'Brien, Tracey, additional, Diaz, Miguel A., additional, Sevilla, Julian, additional, Smith, Owen, additional, Peffault de Latour, Regis, additional, de la Fuente, Josue, additional, Or, Reuven, additional, Van Lint, Maria T., additional, Tolar, Jakub, additional, Aljurf, Mahmoud, additional, Fisher, Alain, additional, Skorobogatova, Elena V., additional, Diaz de Heredia, Cristina, additional, Risitano, Antonio, additional, Dalle, Jean-Hugues, additional, Sedláček, Petr, additional, Ghavamzadeh, Ardeshir, additional, and Dufour, Carlo, additional

Published
2018
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6. Association of aplastic anaemia and lymphoma: a report from the severe aplastic anaemia working party of the European Society of Blood and Bone Marrow Transplantation.

Author

Rovó, Alicia, Kulasekararaj, Austin, Medinger, Michael, Chevallier, Patrice, Ribera, Jose M., Peffault de Latour, Regis, Knol, Cora, Iacobelli, Simona, Kanfer, Edward, Bruno, Benedetto, Maury, Sébastien, Quarello, Paola, Koh, Mickey B. C., Schouten, Harry, Blau, Igor W., Tichelli, André, Hill, Anita, Risitano, Antonio, Passweg, Jakob, and Marsh, Judith

Subjects
APLASTIC anemia, LYMPHOMAS, BONE marrow transplantation, ASSOCIATIONS, institutions, etc., CANCER treatment
Abstract

The article examines diseases characteristics as well as treating centre attitudes concerning the therapy and outcome of patients having aplastic anaemia and lymphoma. The evaluation was peformed by Severe Aplastic Anaemia Working Party of the European Society of Blood and Bone Marrow Transplantation.

Published
2019
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7. Liposomal daunorubicinversusstandard daunorubicin: long term follow-up of the GIMEMA GSI 103 AMLE randomized trial in patients older than 60 years with acute myelogenous leukaemia

Author

Latagliata, Roberto, primary, Breccia, Massimo, additional, Fazi, Paola, additional, Iacobelli, Simona, additional, Martinelli, Giovanni, additional, Di Raimondo, Francesco, additional, Sborgia, Marco, additional, Fabbiano, Francesco, additional, Pirrotta, Maria Teresa, additional, Zaccaria, Alfonso, additional, Amadori, Sergio, additional, Caramatti, Cecilia, additional, Falzetti, Franca, additional, Candoni, Anna, additional, Mattei, Daniele, additional, Morselli, Monica, additional, Alimena, Giuliana, additional, Vignetti, Marco, additional, Baccarani, Michele, additional, and Mandelli, Franco, additional

Published
2008
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8. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita

Author

Julián Sevilla, Paul Veys, E T Korthof, Régis Peffault de Latour, Dorine Bresters, Tracey A. O'Brien, Marco Zecca, Maura Faraci, Simona Iacobelli, Jean Hugues Dalle, Antonio M. Risitano, Luca Arcuri, Maurizio Miano, Francesca Fioredda, Ardeshir Ghavamzadeh, Reuven Or, Miguel Angel Diaz, Brune Mats, E V Skorobogatova, Josue de la Fuente, Cora Knol, Petr Sedlacek, Franca Fagioli, Cristina Díaz de Heredia, Ayami Yoshimi, Michael Maschan, Jakub Tolar, Owen P. Smith, Carlo Dufour, Mahmoud Aljurf, Maria Teresa Van Lint, Alain Fisher, Anja van Biezen, Fioredda, Francesca, Iacobelli, Simona, Korthof, Elisabeth T., Knol, Cora, van Biezen, Anja, Bresters, Dorine, Veys, Paul, Yoshimi, Ayami, Fagioli, Franca, Mats, Brune, Zecca, Marco, Faraci, Maura, Miano, Maurizio, Arcuri, Luca, Maschan, Michael, O'Brien, Tracey, Diaz, Miguel A., Sevilla, Julian, Smith, Owen, Peffault de Latour, Regi, de la Fuente, Josue, Or, Reuven, Van Lint, Maria T., Tolar, Jakub, Aljurf, Mahmoud, Fisher, Alain, Skorobogatova, Elena V., Diaz de Heredia, Cristina, Risitano, Antonio, Dalle, Jean-Hugue, Sedláček, Petr, Ghavamzadeh, Ardeshir, and Dufour, Carlo

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Transplantation Conditioning, Pulmonary Fibrosis, haematopoietic stem cell transplantation, Graft vs Host Disease, Disease, dyskeratosis congenita, Settore MED/01 - Statistica Medica, Young Adult, bone marrow failure, Hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Bone Marrow Diseases, business.industry, Age Factors, Hematopoietic Stem Cell Transplantation, Bone marrow failure, medicine.disease, Survival Analysis, Tissue Donors, Transplantation, Haematopoiesis, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Bone marrow, Stem cell, business, Dyskeratosis congenita, 030215 immunology
Abstract

Dyskeratosis congenita (DC) is a genetic multisystem disorder with frequent involvement of the bone marrow. Haematopoietic stem cell transplantation (HSCT) is the only definitive cure to restore haematopoiesis, even though it cannot correct other organ dysfunctions. We collected data on the outcome of HSCT in the largest cohort of DC (n = 94) patients ever studied. Overall survival (OS) and event-free survival (EFS) at 3 years after HSCT were 66% and 62%, respectively. Multivariate analysis showed better outcomes in patients aged less than 20 years and in patients transplanted from a matched, rather than a mismatched, donor. OS and EFS curves tended to decline over time. Early lethal events were infections, whereas organ damage and secondary malignancies appeared afterwards, even a decade after HSCT. A non-myeloablative conditioning regimen appeared to be most advisable. Organ impairment present before HSCT seemed to favour the development of chronic graft-versus-host disease and T-B immune deficiency appeared to enhance pulmonary fibrosis. According to the present data, HSCT in DC is indicated in cases of progressive marrow failure, whereas in patients with pre-existing organ damage, this should be carefully evaluated. Further efforts to investigate treatment alternatives to HSCT should be encouraged.

Published
2018

9. Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective analysis from the European Society for Blood and Marrow Transplantation (EBMT).

Author

Schetelig J, de Wreede LC, Andersen NS, Moreno C, van Gelder M, Vitek A, Karas M, Michallet M, Machaczka M, Gramatzki M, Beelen D, Finke J, Delgado J, Volin L, Passweg J, Dreger P, Schaap N, Wagner E, Henseler A, van Biezen A, Bornhäuser M, Iacobelli S, Putter H, Schönland SO, and Kröger N

Subjects
Adult, Aged, Delivery of Health Care statistics & numerical data, Europe epidemiology, Female, Humans, Kaplan-Meier Estimate, Karnofsky Performance Status, Leukemia, Lymphocytic, Chronic, B-Cell mortality, Male, Middle Aged, Recurrence, Registries, Retrospective Studies, Risk Factors, Transplantation Conditioning methods, Hematopoietic Stem Cell Transplantation methods, Leukemia, Lymphocytic, Chronic, B-Cell therapy, Professional Practice statistics & numerical data
Abstract

The best approach for allogeneic haematopoietic stem cell transplantations (alloHCT) in patients with chronic lymphocytic leukaemia (CLL) is unknown. We therefore analysed the impact of procedure- and centre-related factors on 5-year event-free survival (EFS) in a large retrospective study. Data of 684 CLL patients who received a first alloHCT between 2000 and 2011 were analysed by multivariable Cox proportional hazards models with a frailty component to investigate unexplained centre heterogeneity. Five-year EFS of the whole cohort was 37% (95% confidence interval [CI], 34-42%). Larger numbers of CLL alloHCTs (hazard ratio [HR] 0·96, P = 0·002), certification of quality management (HR 0·7, P = 0·045) and a higher gross national income per capita (HR 0·4, P = 0·04) improved EFS. In vivo T-cell depletion (TCD) with alemtuzumab compared to no TCD (HR 1·5, P = 0·03), and a female donor compared to a male donor for a male patient (HR 1·4, P = 0·02) had a negative impact on EFS, but not non-myeloablative versus more intensive conditioning. After correcting for patient-, procedure- and centre-characteristics, significant variation in centre outcomes persisted. In conclusion, further research on the impact of centre and procedural characteristics is warranted. Non-myeloablative conditioning appears to be the preferable approach for patients with CLL., (© 2017 John Wiley & Sons Ltd.)

Published
2017
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