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Your search keyword '"Koschmieder, Steffen"' showing total 5 results
Start Over Author "Koschmieder, Steffen" Journal british journal of haematology
5 results on '"Koschmieder, Steffen"'

1. The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double‐blind, double‐dummy, symptom study (RELIEF)

Author

Mesa, Ruben, Vannucchi, Alessandro M., Yacoub, Abdulraheem, Zachee, Pierre, Garg, Mamta, Lyons, Roger, Koschmieder, Steffen, Rinaldi, Ciro, Byrne, Jennifer, Hasan, Yasmin, Passamonti, Francesco, Verstovsek, Srdan, Hunter, Deborah, Jones, Mark M., Zhen, Huiling, Habr, Dany, and Martino, Bruno

Published
2017
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2. Androgen derivatives improve blood counts and elongate telomere length in adult cryptic dyskeratosis congenita

Author

Kirschner, Martin, primary, Vieri, Margherita, additional, Kricheldorf, Kim, additional, Ferreira, Monica S. Ventura, additional, Wlodarski, Marcin W., additional, Schwarz, Michaela, additional, Balabanov, Stefan, additional, Rolles, Benjamin, additional, Isfort, Susanne, additional, Koschmieder, Steffen, additional, Höchsmann, Britta, additional, Panse, Jens, additional, Brümmendorf, Tim H., additional, and Beier, Fabian, additional

Published
2020
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4. Androgen derivatives improve blood counts and elongate telomere length in adult cryptic dyskeratosis congenita.

Author

Kirschner, Martin, Vieri, Margherita, Kricheldorf, Kim, Ferreira, Monica S. Ventura, Wlodarski, Marcin W., Schwarz, Michaela, Balabanov, Stefan, Rolles, Benjamin, Isfort, Susanne, Koschmieder, Steffen, Höchsmann, Britta, Panse, Jens, Brümmendorf, Tim H., and Beier, Fabian

Subjects
TELOMERES, ANDROGENS, BONE marrow, ADULTS, GRANULOCYTES
Abstract

Summary: Dyskeratosis Congenita (DKC) is a systemic disorder caused by mutations resulting in impaired telomere maintenance. Clinical features include bone marrow failure and an increased risk of developing hematological malignancies. There are conflicting data whether androgen derivatives (AD) can elongate telomeres in vivo and whether AD treatment enhances the risk of gaining myelodysplastic syndrome‐related mutations. Seven TERC or TERT‐mutated DKC patients underwent AD treatment. All patients revealed hematological response. Telomere length of lymphocytes and granulocytes increased significantly and no MDS‐related mutations were detected. Pending longer follow‐up, treatment with AD seems to represent an efficient and safe therapy for DKC patients. [ABSTRACT FROM AUTHOR]

Published
2021
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5. The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF)

Author

Mesa, Ruben, primary, Vannucchi, Alessandro M., additional, Yacoub, Abdulraheem, additional, Zachee, Pierre, additional, Garg, Mamta, additional, Lyons, Roger, additional, Koschmieder, Steffen, additional, Rinaldi, Ciro, additional, Byrne, Jennifer, additional, Hasan, Yasmin, additional, Passamonti, Francesco, additional, Verstovsek, Srdan, additional, Hunter, Deborah, additional, Jones, Mark M., additional, Zhen, Huiling, additional, Habr, Dany, additional, and Martino, Bruno, additional

Published
2016
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