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Start Over Author "Palmi, C" Journal british journal of haematology
3 results on '"Palmi, C"'

2. Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

Author

Attarbaschi, A, Morak, M, Cario, G, Cazzaniga, G, Ensor, Hm, TE KRONNIE, Geertrudy, Bradtke, J, Mann, G, Vendramini, E, Palmi, C, Schwab, C, Russell, Lj, Schrappe, M, Conter, V, Mitchell, Cd, Strehl, S, Zimmermann, M, Pötschger, U, Harrison, Cj, Stanulla, M, Panzer Grümayer, R, Haas, Oa, Moorman, Av, Associazione Italiana di Ematologia ed Oncologia Pediatrica Berlin Frankfurt Münster Study Group, National Cancer Research Institute Children's Cancer, Leukaemia Study Group, Attarbaschi, A, Morak, M, Cario, G, Cazzaniga, G, Ensor, H, te Kronnie, T, Bradtke, J, Mann, G, Vendramini, E, Palmi, C, Schwab, C, Russell, L, Schrappe, M, Conter, V, Mitchell, C, Strehl, S, Zimmermann, M, Pötschger, U, Harrison, C, Stanulla, M, Panzer Grümayer, R, Haas, O, and Moorman, A

Subjects
Male, Risk, medicine.medical_specialty, Pediatrics, Study groups, Adolescent, Treatment outcome, Kaplan-Meier Estimate, Acute leukaemia, Recurrence, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Genetics, medicine, Humans, Multicenter Studies as Topic, Receptors, Cytokine, Child, Randomized Controlled Trials as Topic, business.industry, Incidence (epidemiology), Remission Induction, Childhood leukaemia, Infant, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Europe, Treatment Outcome, Child, Preschool, Lymphoblastic leukaemia, Female, business, Follow-Up Studies
Abstract

The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+ , 15 IGH@-CRLF2+ ), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.

Published
2012

3. Pro-inflammatory cytokines favor the emergence of ETV6-RUNX1-positive pre-leukemic cells in a model of mesenchymal niche.

Author

Beneforti L, Dander E, Bresolin S, Bueno C, Acunzo D, Bertagna M, Ford A, Gentner B, Kronnie GT, Vergani P, Menéndez P, Biondi A, D'Amico G, Palmi C, and Cazzaniga G

Subjects
Core Binding Factor Alpha 2 Subunit genetics, Humans, Oncogene Proteins, Fusion genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Translocation, Genetic, Core Binding Factor Alpha 2 Subunit metabolism, Cytokines metabolism, Mesenchymal Stem Cells metabolism, Oncogene Proteins, Fusion metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma metabolism
Abstract

ETV6-RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration in childhood acute lymphoblastic leukemia (ALL). However, E/R is insufficient to cause overt leukemia since it generates a clinically silent pre-leukemic clone which persists in the bone marrow but fails to out-compete normal progenitors. Conversely, pre-leukemic cells show increased susceptibility to transformation following additional genetic insults. Infections/inflammation are the most accredited triggers for mutations accumulation and leukemic transformation in E/R + pre-leukemic cells. However, precisely how E/R and inflammation interact in promoting leukemia is still poorly understood. Here we demonstrate that IL6/TNFα/ILβ pro-inflammatory cytokines cooperate with BM-MSC in promoting the emergence of E/R + Ba/F3 over their normal counterparts by differentially affecting their proliferation and survival. Moreover, IL6/TNFα/ILβ-stimulated BM-MSC strongly attract E/R + Ba/F3 in a CXCR2-dependent manner. Interestingly, E/R-expressing human CD34 + IL7R + progenitors, a putative population for leukemia initiation during development, were preserved in the presence of BM-MSC and IL6/TNFα/ILβ compared to their normal counterparts. Finally, the extent of DNA damage increases within the inflamed niche in both control and E/R-expressing Ba/F3, potentially leading to transformation in the apoptosis-resistant pre-leukemic clone. Overall, our data provide new mechanistic insights into childhood ALL pathogenesis., (© 2020 British Society for Haematology and John Wiley & Sons Ltd.)

Published
2020
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