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Start Over Author "Zanotti, R" Journal british journal of haematology
8 results on '"Zanotti, R"'

6. In leukaemic CD5+B cells the expression of BCL‐2 gene family is shifted toward protection from apoptosis

Author

Gottardi, D., Alfarano, A., De Leo, A. M., Stacchini, A., Aragno, M., Rigo, A., Veneri, D., ZANOTTI, R., Pizzolo, G., and Caligaris‐Cappio, F.

Abstract

This study further investigated the mechanisms that control apoptosis in leukaemic CD5+B cells, and focused on the Bcl‐2 gene family. The pattern of expression of Bcl‐2, Bcl‐xL, Bcl‐xS and Bax genes, selected because of their interrelated role in the control of apoptosis, was analysed in a series of CD5+B‐cell chronic lymphoid leukaemias. Cells from 34 patients with chronic lymphoid leukaemia of B‐cell type (23 B‐chronic lymphocytic leukaemia (B‐CLL) and 11 mantle cell lymphoma (MCL) in leukaemic phase) were investigated. High levels of Bcl‐2 mRNA were observed by Northern blot and high levels of Bcl‐2 protein were detected by cytofluorograph analysis with a specific monoclonal antibody (MAb) in all cases. Strong Bax expression was detected by RT‐PCR in 20/23 B‐CLL cases; Bax was also observed in 8/11 MCL in leukaemic phase with variable degree of intensity. In both B‐CLL and MCL samples the presence of Bax protein was confirmed by cytofluorograph analysis. RT‐PCR detected high levels of Bcl‐xL in 16/23 B‐CLL and in 8/11 MCL in leukaemic phase, whereas Bcl‐xS was detectable in low to trace amounts respectively in 13/23 B‐CLL and in 6/11 MCL in leukaemic phase. According to the functional role of Bcl‐2, Bcl‐xL, Bcl‐xS and Bax, these data indicate that the pattern of Bcl‐2 family genes expression in leukaemic CD5+B cells is skewed toward prevention of apoptosis and may thus favour the relentless accumulation of CD5+leukaemic B cells.

Published
1996
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7. Familial occurrence of systemic and cutaneous mastocytosis in an adult multicentre series.

Author

Tanasi I, Bonifacio M, Pizzolato M, Irene Grifoni F, Sciumè M, Elena C, Benvenuti P, Mannelli F, Parente R, Schena D, Scaffidi L, Bonadonna P, Papayannidis C, Rondoni M, Criscuolo M, Vannucchi AM, Triggiani M, Martinelli G, Krampera M, and Zanotti R

Subjects
Adolescent, Adult, Aged, Amino Acid Substitution, Family, Female, Humans, Male, Middle Aged, Retrospective Studies, Mastocytosis, Cutaneous epidemiology, Mastocytosis, Cutaneous genetics, Mastocytosis, Systemic genetics, Mastocytosis, Systemic metabolism, Mutation, Missense, Proto-Oncogene Proteins c-kit genetics
Published
2021
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8. Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection.

Author

Ambrosetti A, Zanotti R, Pattaro C, Lenzi L, Chilosi M, Caramaschi P, Arcaini L, Pasini F, Biasi D, Orlandi E, D'Adda M, Lucioni M, and Pizzolo G

Subjects
Age Factors, Female, Hepatitis C radiotherapy, Hepatitis C surgery, Humans, Lymphatic Metastasis, Lymphoma, B-Cell, Marginal Zone radiotherapy, Lymphoma, B-Cell, Marginal Zone surgery, Male, Middle Aged, Prognosis, Retrospective Studies, Salivary Gland Neoplasms radiotherapy, Salivary Gland Neoplasms surgery, Sjogren's Syndrome radiotherapy, Sjogren's Syndrome surgery, Survival Rate, Hepacivirus, Hepatitis C complications, Lymphoma, B-Cell, Marginal Zone complications, Salivary Gland Neoplasms complications, Sjogren's Syndrome complications
Abstract

Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 +/- 8%, 94 +/- 6% and 65 +/- 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.

Published
2004
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