928 results on '"C. H."'
Search Results
2. 752 How Do We Manage Open Fractures in Emergency Department? – a Closed Loop Audit
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Li, C H, primary, Banks, J, additional, Zhu, M, additional, and Tucker, H, additional
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- 2023
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3. 1314 Prediction of Raised Intracranial Pressure in Traumatic Brain Injury Patient by Non-Invasive Methods in Lower-Middle Income Countries: Systematic Review and Meta-Analysis
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Dokponou, Y C H, primary, Badirou, O B A, additional, Agada, K N, additional, Dossou, M W, additional, Lawson, L D, additional, Ossaga, M A D, additional, Nyalundja, A D, additional, Adjiou, D K F P, additional, Lassissi, K U, additional, Houndodjade, S M C, additional, Gbenou, F B B, additional, Lantonkpode, R P, additional, Togbenon, N D L, additional, and Bankole, N D A, additional
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- 2023
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4. 1318 Cross-Sectional Study of Recurrent Disc Herniation Risk Factors and Predictors of Outcomes After Primary Lumbar Discectomy: A STROBE Compliance
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Dokponou, Y C H, primary, Obame, F L O, additional, Mouhssani, M, additional, El Akroud, S, additional, Siba, Z, additional, Saad, M E, additional, Sahri, I E, additional, Chandide Tlemcani, Z, additional, Imbunhe, N, additional, Yero, D, additional, Abderrahmane, H, additional, Laaguili, J, additional, El Kacemi, I, additional, Mohcine, S, additional, Belhachmi, A, additional, El Asri, A C, additional, Mostarchid, B, additional, and Gazzaz, M, additional
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- 2023
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5. 1316 Chronic Epidural Hematoma: A Systematic Review and Meta-Analysis
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Agada, N, primary, Bankole, N D A, additional, Badirou, O B A, additional, Nyalundja, A D, additional, Dossou, M W, additional, Lawson, L D, additional, Obame, F L O, additional, Murhega, R B, additional, Togbenon, N D L, additional, Emeka, A C, additional, and Dokponou, Y C H, additional
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- 2023
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6. 513 Surgical Science Secrets - an Innovative Way to Supplement Undergraduate Surgical Education
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Kwan, T Y, primary, Yeo, V, additional, Mukhopadhyay, S, additional, Baskaran, R, additional, Li, C H, additional, Chin, C, additional, and Wijaya, A, additional
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- 2023
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7. 139 “Never Event, Never Again” - a Closed Loop Audit on the Documentation of Nasogastric Tube Position Following X-Ray Confirmation
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Iosif, G, primary, Tan, C H, additional, and McCadden, L, additional
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- 2023
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8. 1175 Management and Outcome of Intracranial Fungal Infections in Africa: A Scoping Review
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Takoutsing, B D, primary, Ooi, S Z Y, additional, Egu, C, additional, Gillespie, C S, additional, Bandyopadhyay, S, additional, Dalle, D U, additional, Erhabor, J, additional, Ciuculete, A C, additional, Kesici, Ö, additional, Awad, A K, additional, Dokponou, Y C H, additional, Khan, M, additional, Ikwuegbuenyi, C A, additional, Dada, O E, additional, and Bankole, N D A, additional
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- 2023
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9. Surgery for multiple endocrine neoplasia type 1-related insulinoma
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van Beek, D. J., Nell, S., Verkooijen, H. M., Borel Rinkes, I. H. M., Valk, G. D., Vriens, M. R., Goudet, P., Vella, A., Donegan, D., Bartsch, D. K., Manoharan, J., Perrier, N. D., Christakis, I., Brandi, M. L., Zarnegar, R., Postma, E. L., Kebebew, E., Nockel, P., Brunaud, L., Pasternak, J. D., Kluijfhout, W. P., Sturgeon, C., Giri, S., Bonsing, B. A., van Eijck, C. H., van Goor, H., de Kleine, R. H. J., van Dijkum, E. J. Nieveen, Dejong, C. H. C., Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Clinical Genetics, and Department of Finance
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Male ,endocrine system diseases ,Kaplan-Meier Estimate ,0302 clinical medicine ,Postoperative Complications ,Multiple endocrine neoplasia ,Child ,Aged, 80 and over ,Middle Aged ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,HPB ,Child, Preschool ,Original Article ,Female ,Pancreas ,hormones, hormone substitutes, and hormone antagonists ,Adult ,medicine.medical_specialty ,endocrine system ,Adolescent ,Enucleation ,Clinical Decision-Making ,030209 endocrinology & metabolism ,Hypoglycemia ,03 medical and health sciences ,Young Adult ,Pancreatectomy ,medicine ,Multiple Endocrine Neoplasia Type 1 ,Humans ,MEN1 ,General ,Survival rate ,Insulinoma ,Aged ,Retrospective Studies ,business.industry ,Original Articles ,medicine.disease ,Surgery ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Pancreatic Neoplasms ,Localized disease ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Background Insulinomas are found in 10–15 per cent of patients with multiple endocrine neoplasia type 1 (MEN1) and lead to life‐threatening hypoglycaemia. Surgical outcome and the optimal surgical strategy for MEN1‐related insulinoma are unknown. Methods Patients with MEN1‐related insulinomas were identified in 46 centres in Europe and North America between 1990 and 2016. Insulinomas were considered localized if the lesion was in the pancreatic head or body/tail. Patients with pancreatic neuroendocrine tumours throughout the pancreas were suspected of having multifocal insulinoma. The primary outcome was postoperative hypoglycaemia, defined as persistent hypoglycaemia, or recurrent hypoglycaemia caused by a new insulinoma or insulin‐producing liver metastases. Hypoglycaemia‐free survival was estimated by the Kaplan–Meier method. Results Ninety‐six patients underwent resection for MEN1‐related insulinoma. Sixty‐three and 33 patients had localized and multifocal insulinomas respectively. After a median follow‐up of 8 (range 1–22) years, one patient (1 per cent) had persistent disease and six (6 per cent) had developed recurrent disease, of whom four had a new insulinoma. The 10‐year hypoglycaemia‐free survival rate was 91 (95 per cent c.i. 80 to 96) per cent. Of those with localized disease, 46 patients underwent pancreatic resection and 17 enucleation. One of these patients had persistent disease and one developed recurrent insulinoma. Among patients with multifocal disease, three developed new insulinomas and two developed insulin‐producing liver metastases. Conclusion Surgery for MEN1‐related insulinoma is more successful than previously thought., In this cohort of 96 patients with resected multiple endocrine neoplasia 1 (MEN1)‐related insulinomas, seven patients (7 per cent) developed postoperative persistent or recurrent hypoglycaemia after a median follow‐up of 8 years. The 10‐year hypoglycaemia‐free survival rate was 91 (95 per cent c.i. 80 to 96) per cent. For patients with localized insulinoma, enucleation seems the preferred procedure. PPPD, pylorus‐preserving pancreatoduodenectomy. Outcomes good
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- 2020
10. Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors
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Hosgood, S. A., Thompson, E., Moore, T., Wilson, C. H., and Nicholson, M. L.
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- 2018
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11. Patient‐derived organoid models help define personalized management of gastrointestinal cancer
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Aberle, M. R., Burkhart, R. A., Tiriac, H., Olde Damink, S. W. M., Dejong, C. H. C., Tuveson, D. A., and van Dam, R. M.
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- 2018
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12. Nationwide outcomes in patients undergoing surgical exploration without resection for pancreatic cancer
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van der Geest, L. G. M., Lemmens, V. E. P. P., de Hingh, I. H. J. T., van Laarhoven, C. J. H. M., Bollen, T. L., Nio, C. Y., van Eijck, C. H. J., Busch, O. R. C., and Besselink, M. G.
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- 2017
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13. Three-point transfusion risk score in hepatectomy
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Lemke, M., Law, C. H. L., Li, J., Dixon, E., Tun Abraham, M., Hernandez Alejandro, R., Bennett, S., Martel, G., and Karanicolas, P. J.
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- 2017
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14. Meta‐analysis of individual‐patient data from EVAR‐1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years
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Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J.‐P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D. G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R.J., Bell, P. R. F., Greenhalgh, R. M., Whitaker, S.C., Poole‐Wilson, the late P.A., Ruckley, C. V., Campbell, W. B., Dean, M. R. E., Ruttley, M. S. T., Coles, E. C., Powell, J. T., Halliday, A., Gibbs, S. J., Brown, L. C., Epstein, D., Sculpher, M. J., Thompson, S. G., Hannon, R. J., Johnston, L., Bradbury, A. W., Henderson, M. J., Parvin, S. D., Shepherd, D. F. C., Greenhalgh, R. M., Mitchell, A. W., Edwards, P. R., Abbott, G. T., Higman, D. J., Vohra, A., Ashley, S., Robottom, C., Wyatt, M. G., Rose, J. D. G., Byrne, D., Edwards, R., Leiberman, D. P., McCarter, D. H., Taylor, P. R., Reidy, J. F., Wilkinson, A. R., Ettles, D. F., Clason, A. E., Leen, G. L. S., Wilson, N. V., Downes, M., Walker, S. R., Lavelle, J. M., Gough, M. J., McPherson, S., Scott, D. J. A., Kessell, D. O., Naylor, R., Sayers, R., Fishwick, N. G., Harris, P. L., Gould, D. A., Walker, M. G., Chalmers, N. C., Garnham, A., Collins, M. A., Beard, J. D., Gaines, P. A., Ashour, M. Y., Uberoi, R., Braithwaite, B., Whitaker, S. C., Davies, J. N., Travis, S., Hamilton, G., Platts, A., Shandall, A., Sullivan, B. A., Sobeh, M., Matson, M., Fox, A. D., Orme, R., Yusef, W., Doyle, T., Horrocks, M., Hardman, J., Blair, P. H. B., Ellis, P. K., Morris, G., Odurny, A., Vohra, R., Duddy, M., Thompson, M., Loosemore, T. M. L., Belli, A. M., Morgan, R., Adiseshiah, M., Brookes, J. A. S., McCollum, C. N., Ashleigh, R., Aukett, M., Baker, S., Barbe, E., Batson, N., Bell, J., Blundell, J., Boardley, D., Boyes, S., Brown, O., Bryce, J., Carmichael, M., Chance, T., Coleman, J., Cosgrove, C., Curran, G., Dennison, T., Devine, C., Dewhirst, N., Errington, B., Farrell, H., Fisher, C., Fulford, P., Gough, M., Graham, C., Hooper, R., Horne, G., Horrocks, L., Hughes, B., Hutchings, T., Ireland, M., Judge, C., Kelly, L., Kemp, J., Kite, A., Kivela, M., Lapworth, M., Lee, C., Linekar, L., Mahmood, A., March, L., Martin, J., Matharu, N., McGuigen, K., Morris‐Vincent, P., Murray, S., Murtagh, A., Owen, G., Ramoutar, V., Rippin, C., Rowley, J., Sinclair, J., Spencer, S., Taylor, V., Tomlinson, C., Ward, S., Wealleans, V., West, J., White, K., Williams, J., Wilson, L., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A. A., Buth, J., Pattynama, P. M., Verhoeven, E. L. G., van Voorthuisen, A. E., Blankensteijn, J. D., Balm, R., Buth, J., Cuypers, P. W. M., Grobbee, D. E., Prinssen, M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J. H. M., de Mol, B. A. J. M., van Bockel, J. H., Balm, R., Reekers, J., Tielbeek, X., Verhoeven, E. L. G., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., Prinssen, M., Balm, R., Blankensteijn, J. D., Buth, J., Cuypers, P. W. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., de Bruin, J. L., Baas, A. F., Blankensteijn, J. D., Prinssen, M., Buth, J., Tielbeek, A.V., Blankensteijn, J. D., Balm, R., Reekers, J. A., van Sambeek, M. R. H. M., Pattynama, P., Verhoeven, E. L. G., Prins, T., van der Ham, A. C., van der Velden, J. J. I. M., van Sterkenburg, S. M. M., ten Haken, G. B., Bruijninckx, C. M. A., van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A. W., Odink, H. F., de Smet, A. A. E. A., Vroegindeweij, D., van Loenhout, R. M. M., Rutten, M. J., Hamming, J. F., Lampmann, L. E. H., Bender, M. H. M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J. C., van Dortmont, L. M. C., van der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H. B., van Dop, H. R., de Mol van Otterloo, J. C. A., de Rooij, T. P. W., Smits, T. M., Yilmaz, E. N., Wisselink, W., van den Berg, F. G., Visser, M. J. T., van der Linden, E., Schurink, G. W. H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., Vermassen, F. E. G., Lederle, F. A., Freischlag, J. A., Kohler, T. R., Latts, E., Matsumura, J., Padberg, F. T., Jr, Kyriakides, T. C., Swanson, K. M., Guarino, P., Peduzzi, P., Antonelli, M., Cushing, C., Davis, E., Durant, L., Joyner, S., Kossack, the late A., Kyriakides, T. C., LeGwin, Mary, McBride, V., OʼConnor, T., Poulton, J., Stratton, the late S., Zellner, S., Snodgrass, A. J., Thornton, J., Swanson, K. M., Haakenson, C. M., Stroupe, K.T., Jonk, Y., Hallett, J. W., Hertzer, N., Towne, J., Katz, D. A., Karrison, T., Matts, J. P., Marottoli, R., Kasl, S., Mehta, R., Feldman, R., Farrell, W., Allore, H., Perry, E., Niederman, J., Randall, F., Zeman, M., Beckwith, the late D., OʼLeary, T. J., Huang, G. D., Latts, E., Bader, M., Ketteler, E. R., Kingsley, D. D., Marek, J. M., Massen, R. J., Matteson, B. D., Pitcher, J. D., Langsfeld, M., Corson, J. D., Goff, J. M., Jr, Kasirajan, K., Paap, C., Robertson, D. C., Salam, A., Veeraswamy, R., Milner, R., Kasirajan, K., Guidot, J., Lal, B. K., Busuttil, S. J., Lilly, M. P., Braganza, M., Ellis, K., Patterson, M. A., Jordan, W. D., Whitley, D., Taylor, S., Passman, M., Kerns, D., Inman, C., Poirier, J., Ebaugh, J., Raffetto, J., Chew, D., Lathi, S., Owens, C., Hickson, K., Dosluoglu, H. H., Eschberger, K., Kibbe, M. R., Baraniewski, H. M., Matsumura, J., Endo, M., Busman, A., Meadows, W., Evans, M., Giglia, J. S., El Sayed, H., Reed, A. B., Ruf, M., Ross, S., Jean‐Claude, J. M., Pinault, G., Kang, P., White, N., Eiseman, M., Jones, the late R., Timaran, C. H., Modrall, J. G., Welborn, M. B., III, Lopez, J., Nguyen, T., Chacko, J. K. Y., Granke, K., Vouyouka, A. G., Olgren, E., Chand, P., Allende, B., Ranella, M., Yales, C., Whitehill, T. A., Krupski, the late W. C., Nehler, M. R., Johnson, S. P., Jones, D. N., Strecker, P., Bhola, M. A., Shortell, C. K., Gray, J. L., Lawson, J. H., McCann, R., Sebastian, M.W., Kistler Tetterton, J., Blackwell, C., Prinzo, P. A., Lee, N., Padberg, F. T., Jr, Cerveira, J. J., Lal, B. K., Zickler, R. W., Hauck, K. A., Berceli, S. A., Lee, W. A., Ozaki, C. K., Nelson, P. R., Irwin, A. S., Baum, R., Aulivola, B., Rodriguez, H., Littooy, F. N., Greisler, H., OʼSullivan, M. T., Kougias, P., Lin, P. H., Bush, R. L., Guinn, G., Bechara, C., Cagiannos, C., Pisimisis, G., Barshes, N., Pillack, S., Guillory, B., Cikrit, D., Lalka, S. G., Lemmon, G., Nachreiner, R., Rusomaroff, M., OʼBrien, E., Cullen, J. J., Hoballah, J., Sharp, W. J., McCandless, J. L., Beach, V., Minion, D., Schwarcz, T. H., Kimbrough, J., Ashe, L., Rockich, A., Warner‐Carpenter, J., Moursi, M., Eidt, J. F., Brock, S., Bianchi, C., Bishop, V., Gordon, I. L., Fujitani, R., Kubaska, S. M., III, Behdad, M., Azadegan, R., Ma Agas, C., Zalecki, K., Hoch, J. R., Carr, S. C., Acher, C., Schwarze, M., Tefera, G., Mell, M., Dunlap, B., Rieder, J., Stuart, J. M., Weiman, D. S., Abul‐Khoudoud, O., Garrett, H. E., Walsh, S. M., Wilson, K. L., Seabrook, G. R., Cambria, R. A., Brown, K. R., Lewis, B. D., Framberg, S., Kallio, C., Barke, R. A., Santilli, S. M., dʼAudiffret, A. C., Oberle, N., Proebstle, C., Johnson, L. L., Jacobowitz, G. R., Cayne, N., Rockman, C., Adelman, M., Gagne, P., Nalbandian, M., Caropolo, L. J., Pipinos, I. I., Johanning, J., Lynch, T., DeSpiegelaere, H., Purviance, G., Zhou, W., Dalman, R., Lee, J. T., Safadi, B., Coogan, S. M., Wren, S. M., Bahmani, D. D., Maples, D., Thunen, S., Golden, M. A., Mitchell, M. E., Fairman, R., Reinhardt, S., Wilson, M. A., Tzeng, E., Muluk, S., Peterson, N. M., Foster, M., Edwards, J., Moneta, G. L., Landry, G., Taylor, L., Yeager, R., Cannady, E., Treiman, G., Hatton‐Ward, S., Salabsky, the late B., Kansal, N., Owens, E., Estes, M., Forbes, B. A., Sobotta, C., Rapp, J. H., Reilly, L. M., Perez, S. L., Yan, K., Sarkar, R., Dwyer, S. S., Perez, S., Chong, K., Kohler, T. R., Hatsukami, T. S., Glickerman, D. G., Sobel, M., Burdick, T. S., Pedersen, K., Cleary, P., Back, M., Bandyk, D., Johnson, B., Shames, M., Reinhard, R. L., Thomas, S. C., Hunter, G. C., Leon, L. R., Jr, Westerband, A., Guerra, R. J., Riveros, M., Mills, J. L., Sr, Hughes, J. D., Escalante, A. M., Psalms, S. B., Day, N. N., Macsata, R., Sidawy, A., Weiswasser, J., Arora, S., Jasper, B. J., Dardik, A., Gahtan, V., Muhs, B. E., Sumpio, B. E., Gusberg, R. J., Spector, M., Pollak, J., Aruny, J., Kelly, E. L., Wong, J., Vasilas, P., Joncas, C., Gelabert, H. A., DeVirgillio, C., Rigberg, D. A., Cole, L., Becquemin, J.‐P., Marzelle, J., Becquemin, J.‐P., Sapoval, M., Becquemin, J.‐P., Favre, J.‐P., Watelet, J., Lermusiaux, P., Sapoval, M., Lepage, E., Hemery, F., Dolbeau, G., Hawajry, N., Cunin, P., Harris, P., Stockx, L., Chatellier, G., Mialhe, C., Fiessinger, J.‐N., Pagny, L., Kobeiter, H., Boissier, C., Lacroix, P., Ledru, F., Pinot, J.‐J., Deux, J.‐F., Tzvetkov, B., Duvaldestin, P., Watelet, J., Jourdain, C., David, V., Enouf, D., Ady, N., Krimi, A., Boudjema, N., Jousset, Y., Enon, B., Blin, V., Picquet, J., LʼHoste, P., Thouveny, F., Borie, H., Kowarski, S., Pernes, J.‐M., Auguste, M., Becquemin, J.‐P., Desgranges, P., Allaire, E., Marzelle, J., Kobeiter, H., Meaulle, P.‐Y., Chaix, D., Juliae, P., Fabiani, J. N., Chevalier, P., Combes, M., Seguin, A., Belhomme, D., Sapoval, M., Baque, J., Pellerin, O., Favre, J. P., Barral, X., Veyret, C., Watelet, J., Peillon, C., Plissonier, D., Thomas, P., Clavier, E., Lermusiaux, P., Martinez, R., Bleuet, F., C, Dupreix, Verhoye, J. P., Langanay, T., Heautot, J. F., Koussa, M., Haulon, S., Halna, P., Destrieux, L., Lions, C., Wiloteaux, S., Beregi, J. P., Bergeron, P., Pinot, J.‐J., Patra, P., Costargent, A., Chaillou, P., DʼAlicourt, A., Goueffic, Y., Cheysson, E., Parrot, A., Garance, P., Demon, A., Tyazi, A., Pillet, J.‐C., Lescalie, F., Tilly, G., Steinmetz, E., Favier, C., Brenot, R., Krause, D., Cercueil, J. P., Vahdat, O., Sauer, M., Soula, P., Querian, A., Garcia, O., Levade, M., Colombier, D., Cardon, J.‐M., Joyeux, A., Borrelly, P., Dogas, G., Magnan, P.‐É., Branchereau, A., Bartoli, J.‐M., Hassen‐Khodja, R., Batt, M., Planchard, P.‐F., Bouillanne, P.‐J., Haudebourg, P., Bayne, J., Gouny, P., Badra, A., Braesco, J., Nonent, M., Lucas, A., Cardon, A., Kerdiles, Y., Rolland, Y., Kassab, M., Brillu, C., Goubault, F., Tailboux, L., Darrieux, H., Briand, O., Maillard, J.‐C., Varty, K., and Cousins, C.
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- 2017
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15. Cost‐effectiveness of emergency versus delayed laparoscopic cholecystectomy for acute gallbladder pathology
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Sutton, A. J., Vohra, R. S., Hollyman, M., Marriott, P. J., Buja, A., Alderson, D., Pasquali, S., Griffiths, E. A., Vohra, R. S., Spreadborough, P., Hollyman, M., Marriott, P. J., Kirkham, A., Pasquali, S., Alderson, D., Griffiths, E. A., Fenwick, S., Elmasry, M., Nunes, Q. M., Kennedy, D., Khan, R. B., Khan, M. A. S., Magee, C. J., Jones, S. M., Mason, D., Parappally, C. P., Mathur, P., Saunders, M., Jamel, S., Ul Haque, S., Zafar, S., Shiwani, M. H., Samuel, N., Dar, F., Jackson, A., Lovett, B., Dindyal, S., Winter, H., Fletcher, T., Rahman, S., Wheatley, K., Nieto, T., Ayaani, S., Youssef, H., Nijjar, R. S., Watkin, H., Naumann, D., Emesih, S., Sarmah, P. B., Lee, K., Joji, N., Heath, J., Teasdale, R. L., Weerasinghe, C., Needham, P. J., Welbourn, H., Forster, L., Finch, D., Blazeby, J. M., Robb, W., McNair, A. G. K., Hrycaiczuk, A., Charalabopoulos, A., Kadirkamanathan, S., Tang, C.‐B., Jayanthi, N. V. G., Noor, N., Dobbins, B., Cockbain, A. J., Nilsen‐Nunn, A., de Siqueira, J., Pellen, M., Cowley, J. B., Ho, W.‐M., Miu, V., White, T. J., Hodgkins, K. A., Kinghorn, A., Tutton, M. G., Al‐Abed, Y. A., Menzies, D., Ahmad, A., Reed, J., Khan, S., Monk, D., Vitone, L. J., Murtaza, G., Joel, A., Brennan, S., Shier, D., Zhang, C., Yoganathan, T., Robinson, S. J., McCallum, I. J. D., Jones, M. J., Elsayed, M., Tuck, E., Wayman, J., Carney, K., Aroori, S., Hosie, K. B., Kimble, A., Bunting, D.M., Fawole, A. S., Basheer, M., Dave, R. V., Sarveswaran, J., Jones, E., Kendal, C., Tilston, M. P., Gough, M., Wallace, T., Singh, S., Downing, J., Mockford, K. A., Issa, E., Shah, N., Chauhan, N., Wilson, T. R., Forouzanfar, A., Wild, J. R. L., Nofal, E., Bunnell, C., Madbak, K., Rao, S. T. V., Devoto, L., Siddiqi, N., Khawaja, Z., Hewes, J. C., Gould, L., Chambers, A., Rodriguez, D. U., Sen, G., Robinson, S., Carney, K., Bartlett, F., Rae, D. M., Stevenson, T. E. J., Sarvananthan, K., Dwerryhouse, S. J., Higgs, S. M., Old, O. J., Hardy, T. J., Shah, R., Hornby, S. T., Keogh, K., Frank, L., Al‐Akash, M., Upchurch, E. A., Frame, R. J., Hughes, M., Jelley, C., Weaver, S., Roy, S., Sillo, T. O., Galanopoulos, G., Cuming, T., Cunha, P., Tayeh, S., Kaptanis, S., Heshaishi, M., Eisawi, A., Abayomi, M., Ngu, W. S., Fleming, K., Bajwa, D. S., Chitre, V., Aryal, K., Ferris, P., Silva, M., Lammy, S., Mohamed, S., Khawaja, A., Hussain, A., Ghazanfar, M. A., Bellini, M. I., Ebdewi, H., Elshaer, M., Gravante, G., Drake, B., Ogedegbe, A., Mukherjee, D., Arhi, C., Iqbal, L. G. N., Watson, N. F., Aggarwal, S. K., Orchard, P., Villatoro, E., Willson, P. D., Mok, J., Woodman, T., Deguara, J., Garcea, G., Babu, B. I., Dennison, A. R., Malde, D., Lloyd, D., Satheesan, S., Al‐Taan, O., Boddy, A., Slavin, J. P., Jones, R. P., Ballance, L., Gerakopoulos, S., Jambulingam, P., Mansour, S., Sakai, N., Acharya, V., Sadat, M. M., Karim, L., Larkin, D., Amin, K., Khan, A., Law, J., Jamdar, S., Smith, S. R., Sampat, K., Oʼshea, K. M., Manu, M., Asprou, F. M., Malik, N. S., Chang, J., Johnstone, M., Lewis, M., Roberts, G. P., Karavadra, B., Photi, E., Hewes, J., Gould, L., Chambers, A., Rodriguez, D., OʼReilly, D. A., Rate, A. J., Sekhar, H., Henderson, L. T., Starmer, B. Z., Coe, P. O., Tolofari, S., Barrie, J., Bashir, G., Sloane, J., Madanipour, S., Halkias, C., Trevatt, A. E. J., Borowski, D. W., Hornsby, J., Courtney, M. J., Virupaksha, S., Seymour, K., Robinson, S., Hawkins, H., Bawa, S., Gallagher, P. V., Reid, A., Wood, P., Finch, J. G., Parmar, J., Stirland, E., Gardner‐Thorpe, J., Al‐Muhktar, A., Peterson, M., Majeed, A., Bajwa, F. M., Martin, J., Choy, A., Tsang, A., Pore, N., Andrew, D. R., Al‐Khyatt, W., Taylor, C., Bhandari, S., Chambers, A., Subramanium, D., Toh, S. K. C., Carter, N. C., Tate, S., Pearce, B., Wainwright, D., Mercer, S. J., Knight, B., Vijay, V., Alagaratnam, S., Sinha, S., Khan, S., El‐Hasani, S. S., Hussain, A. A., Bhattacharya, V., Kansal, N., Fasih, T., Jackson, C., Siddiqui, M. N., Chishti, I. A., Fordham, I. J., Siddiqui, Z., Bausbacher, H., Geogloma, I., Gurung, K., Tsavellas, G., Basynat, P., Shrestha, A. K., Basu, S., Mohan, A. C., Harilingam, M., Rabie, M., Akhtar, M., Kumar, P., Jafferbhoy, S. F., Hussain, N., Raza, S., Haque, M., Alam, I., Aseem, R., Patel, S., Asad, M., Booth, M. I., Ball, W. R., Wood, C. P. J., Pinho‐Gomes, A. C., Kausar, A., Obeidallah, M. R., Varghase, J., Lodhia, J., Bradley, D., Rengifo, C., Lindsay, D., Gopalswamy, S., Finlay, I., Wardle, S., Bullen, N., Iftikhar, S. Y., Awan, A., Ahmed, J., Leeder, P., Fusai, G., Bond‐Smith, G., Psica, A., Puri, Y., Hou, D., Noble, F., Szentpali, K., Broadhurst, J., Date, R., Hossack, M. R., Goh, Y. L., Turner, P., Shetty, V., Riera, M., Macano, C. A.W., Sukha, A., Preston, S. R., Hoban, J. R., Puntis, D. J., Williams, S. V., Krysztopik, R., Kynaston, J., Batt, J., Doe, M., Goscimski, A., Jones, G. H., Smith, S. R., Hall, C., Carty, N., Ahmed, J., Panteleimonitis, S., Gunasekera, R. T., Sheel, A. R. G., Lennon, H., Hindley, C., Reddy, M., Kenny, R., Elkheir, N., McGlone, E. R., Rajaganeshan, R., Hancorn, K., Hargreaves, A., Prasad, R., Longbotham, D. A., Vijayanand, D., Wijetunga, I., Ziprin, P., Nicolay, C. R., Yeldham, G., Read, E., Gossage, J. A., Rolph, R. C., Ebied, H., Phull, M., Khan, M. A., Popplewell, M., Kyriakidis, D., Hussain, A., Henley, N., Packer, J. R., Derbyshire, L., Porter, J., Appleton, S., Farouk, M., Basra, M., Jennings, N. A., Ali, S., Kanakala, V., Ali, H., Lane, R., Dickson‐Lowe, R., Zarsadias, P., Mirza, D., Puig, S., Al Amari, K., Vijayan, D., Sutcliffe, R., Marudanayagam, R., Hamady, Z., Prasad, A. R., Patel, A., Durkin, D., Kaur, P., Bowen, L., Byrne, J. P., Pearson, K. L., Delisle, T. G., Davies, J., Tomlinson, M. A., Johnpulle, M. A., Slawinski, C., Macdonald, A., Nicholson, J., Newton, K., Mbuvi, J., Farooq, A., Mothe, B. S., Zafrani, Z., Brett, D., Francombe, J., Spreadborough, P., Barnes, J., Cheung, M., Al‐Bahrani, A. Z., Preziosi, G., Urbonas, T., Alberts, J., Mallik, M., Patel, K., Segaran, A., Doulias, T., Sufi, P. A., Yao, C., Pollock, S., Manzelli, A., Wajed, S., Kourkulos, M., Pezzuto, R., Wadley, M., Hamilton, E., Jaunoo, S., Padwick, R., Sayegh, M., Newton, R. C., Hebbar, M., Farag, S. F., Spearman, J., Hamdan, M. F., DʼCosta, C., Blane, C., Giles, M., Peter, M. B., Hirst, N. A., Hossain, T., Pannu, A., El‐Dhuwaib, Y., Morrison, T. E. M., Taylor, G. W., Thompson, R. L. E., McCune, K., Loughlin, P., Lawther, R., Byrnes, C. K., Simpson, D. J., Mawhinney, A., Warren, C., McKay, D., McIlmunn, C., Martin, S., MacArtney, M., Diamond, T., Davey, P., Jones, C., Clements, J.M., Digney, R., Chan, W. M., McCain, S., Gull, S., Janeczko, A., Dorrian, E., Harris, A., Dawson, S., Johnston, D., McAree, B., Ghareeb, E., Thomas, G., Connelly, M., McKenzie, S., Cieplucha, K., Spence, G., Campbell, W., Hooks, G., Bradley, N., Hill, A. D. K., Cassidy, J. T., Boland, M., Burke, P., Nally, D. M., Hill, A. D. K., Khogali, E., Shabo, W., Iskandar, E., McEntee, G. P., OʼNeill, M. A., Peirce, C., Lyons, E. M., OʼSullivan, A. W., Thakkar, R., Carroll, P., Ivanovski, I., Balfe, P., Lee, M., Winter, D. C., Kelly, M. E., Hoti, E., Maguire, D., Karunakaran, P., Geoghegan, J. G., McDermott, F., Martin, S. T., Cross, K. S., Cooke, F., Zeeshan, S., Murphy, J. O., Mealy, K., Mohan, H. M., Nedujchelyn, Y., Ullah, M. F., Ahmed, I., Giovinazzo, F., Milburn, J., Prince, S., Brooke, E., Buchan, J., Khalil, A. M., Vaughan, E. M., Ramage, M. I., Aldridge, R. C., Gibson, S., Nicholson, G. A., Vass, D. G., Grant, A. J., Holroyd, D. J., Jones, M. A., Sutton, C. M. L. R., OʼDwyer, P., Nilsson, F., Weber, B., Williamson, T. K., Lalla, K., Bryant, A., Carter, C. R., Forrest, C. R., Hunter, D. I., Nassar, A. H., Orizu, M. N., Knight, K., Qandeel, H., Suttie, S., Belding, R., McClarey, A., Boyd, A. T., Guthrie, G. J. K., Lim, P. J., Luhmann, A., Watson, A. J. M., Richards, C. H., Nicol, L., Madurska, M., Harrison, E., Boyce, K. M., Roebuck, A., Ferguson, G., Pati, P., Wilson, M. S. J., Dalgaty, F., Fothergill, L., Driscoll, P. J., Mozolowski, K. L., Banwell, V., Bennett, S. P., Rogers, P. N., Skelly, B. L., Rutherford, C. L., Mirza, A. K., Lazim, T., Lim, H. C. C., Duke, D., Ahmed, T., Beasley, W. D., Wilkinson, M. D., Maharaj, G., Malcolm, C., Brown, T. H., Shingler, G. M., Mowbray, N., Radwan, R., Morcous, P., Wood, S., Kadhim, A., Stewart, D. J., Baker, A. L., Tanner, N., Shenoy, H., Hafiz, S., De Marchi, J. A., Singh‐Ranger, D., Hisham, E., Ainley, P., OʼNeill, S., Terrace, J., Napetti, S., Hopwood, B., Rhys, T., Downing, J., Kanavati, O., Coats, M., Aleksandrov, D., Kallaway, C., Yahya, S., Weber, B., Templeton, A., Trotter, M., Lo, C., Dhillon, A., Heywood, N., Aawsaj, Y., Hamdan, A., Reece‐Bolton, O., McGuigan, A., Shahin, Y., Ali, A., Luther, A., Nicholson, J. A., Rajendran, I., Boal, M., and Ritchie, J.
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- 2017
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16. 46 The Hidden Truth About Gender Bias in Surgery. A Systematic Review
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Wong, C, primary, Lim, W H, additional, Jain, S R, additional, Ng, C H, additional, Tai, C H, additional, Devi, M K, additional, Samarasekera, D D, additional, Iyer, S G, additional, and Chong, C S, additional
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- 2021
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17. 1559 Motivations of Medical Students and Doctors Leaving the NHS Explored in a Residency Training Application Webinar Series
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Ooi, S Z Y, primary, Ooi, R, additional, Godoi, A, additional, Foo, E F, additional, Woo, T, additional, Ganesananthan, S, additional, and Li, C H, additional
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- 2021
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18. Global parental leave in surgical careers: differences according to gender, geographical regions and surgical career stages
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Au, S, primary, Bellato, V, additional, Carvas, J M, additional, Córdoba, C D, additional, Daudu, D, additional, Dziakova, J, additional, Eltarhoni, K, additional, El Feituri, N, additional, Fung, A C H, additional, Fysaraki, C, additional, Gallo, G, additional, Gultekin, F Ayca, additional, Harbjerg, J L, additional, Hatem, F, additional, Ioannidis, A, additional, Jakobsen, L, additional, Clinch, D, additional, Kristensen, H Ø, additional, Kuiper, S Z, additional, Kwok, A M F, additional, Kwok, W, additional, Millan, M, additional, Milto, K M, additional, Ng, H J, additional, Pellino, G, additional, Picciariello, A, additional, Pronin, S, additional, van Ramshorst, G H, additional, Ramser, M, additional, Jiménez-Rodríguez, R M, additional, Sainz Hernandez, J C, additional, Samadov, E, additional, Sohrabi, S, additional, Uchiyama, M, additional, Wang, J H-S, additional, Younis, M U, additional, Fleming, S, additional, Alhomoud, S, additional, Mayol, J, additional, Moeslein, G, additional, Smart, N J, additional, Soreide, K, additional, Teh, C, additional, Verran, D, additional, and Maeda, Y, additional
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- 2021
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19. O51 The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study
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C H Lim, George Kaar, Yvonne M. Nolan, Noel Fanning, Michael Itak Ita, Henry Paul Redmond, Jianghuai Wang, André Toulouse, and Martin J. O’Sullivan
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Messenger RNA ,business.industry ,Cancer ,RNA ,Inflammation ,medicine.disease ,Cell-Free Nucleic Acids ,Glioma ,Cancer research ,Medicine ,Biomarker (medicine) ,Surgery ,medicine.symptom ,business ,Gene - Abstract
Introduction Research into the potential utility of plasma-derived circulating cell-free nucleic acids as non-invasive adjuncts to radiological imaging has been occasioned by the invasive nature of brain tumour biopsy. Circulating-cell-free messenger RNAs are short fragments of RNA present in blood. The objective of this study was to determine whether significant differences exist in the plasma transcriptomic profile of glioma patients relative to differences in their tumour characteristics, and also whether any observed differences were representative of synchronously obtained glioma samples and TCGA glioma derived RNA. Method Blood samples were collected from twenty-nine patients prior to tumour resection. Plasma ccfmRNA and glioma derived RNA were extracted and profiled. Result BCL2L1, CXCL5, GZMB, HLA-A, HLA-C, IRF1, MYD88, TGFB1, TLR2, and TP53 genes were significantly over-expressed in glioma (high-grade-glioma-HGG and low-grade-glioma-LGG) patients (P Conclusion We identified significant differential expression of genes involved in cancer inflammation and immunity among patients with different glioma grades, and we identified positive correlation between the plasma transcriptomic profile and tumour samples, and with TCGA glioma derived RNA. Take-home Message The plasma transcriptomic profile of glioma patients appears to be representative of synchronously obtained glioma samples.
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- 2021
20. O52 Plasma circulating cell-free messenger RNA as a potential biomarker of melanoma
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George Kaar, Jianghuai Wang, Michael Itak Ita, Henry Paul Redmond, Noel Fanning, and C H Lim
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Messenger RNA ,business.industry ,Melanoma ,medicine.medical_treatment ,Cancer ,Immunotherapy ,medicine.disease ,Cell-Free Nucleic Acids ,Granulocyte macrophage colony-stimulating factor ,Gene expression ,Cancer research ,Medicine ,Surgery ,business ,Gene ,medicine.drug - Abstract
Introduction Blood-borne cell-free nucleic acids are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. In this study, we sought to examine whether significant differences exist in the plasma transcriptomic profile of advanced melanoma patients with a high disease burden compared to patients with therapeutic response. Method Plasma circulating cell-free messenger ribonucleic acid (ccfmRNA) was extracted from twenty patients with stage IV melanoma receiving immunotherapy. Pathway focused gene expression analysis was performed. Patients were assessed with paired blood sample collection and CT scan assessments at baseline and at 3 months follow up. Response Evaluation Criteria in Solid Tumours (RECIST 1.1) was used for tumour burden estimation. Result In stage IV melanoma patients, CCL5, GZMB and MYD88 genes were significantly over-expressed (P Conclusion Significant differences were observed in the plasma transcriptomic profile between the various melanoma patient groups, and we postulate that these differences may be exploited to identify novel therapeutic targets or biomarkers relevant to melanoma. CCL4 and CCL5 are prognostic in melanoma, both genes had significantly higher expressions in low disease burden patients compared to patients with a high disease burden. Take-home Message CCL4 and CCL5 ccfmRNA transcripts are prognostic in melanoma. High expression of both genes is favourable in melanoma patients.
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- 2021
21. Ex vivo normothermic machine perfusion facilitates gymnotic delivery of RNA interference therapeutics in donor kidneys
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E R Thompson, A Sewpaul, R Figuereido, L Bates, J R Ferdinand, C M Connelly, S A Hosgood, M L Nicholson, M R Clatworthy, S Ali, C H Wilson, and N S Sheerin
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Surgery - Published
- 2021
22. Early diagnosis of necrotizing fasciitis
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Goh, T., Goh, L. G., Ang, C. H., and Wong, C. H.
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- 2014
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23. Impact of multimodal therapy in locally recurrent rectal cancer
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You, Y. N., Skibber, J. M., Hu, C.-Y., Crane, C. H., Das, P., Kopetz, E. S., Eng, C., Feig, B. W., Rodriguez-Bigas, M. A., and Chang, G. J.
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- 2016
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24. Influence of body composition profile on outcomes following colorectal cancer surgery
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Malietzis, G., Currie, A. C., Athanasiou, T., Johns, N., Anyamene, N., Glynne-Jones, R., Kennedy, R. H., Fearon, K. C. H., and Jenkins, J. T.
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- 2016
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25. Case-matched comparison of ABO-incompatible and ABO-compatible living donor liver transplantation
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Kim, J. M., Kwon, C. H. D., Joh, J.-W., Han, S. B., Sinn, D. H., Choi, G.-S., Kang, E.-S., Lee, J. H., Kim, G. S., and Lee, S.-K.
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- 2016
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26. Experimental study of the potential hazards of surgical smoke from powered instruments
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In, S. M., Park, D.-Y., Sohn, I. K., Kim, C.-H., Lim, H. L., Hong, S.-A., Jung, D. Y., Jeong, S.-Y., Han, J. H., and Kim, H. J.
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- 2015
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27. 10 Complete Mesocolic Excision Produces Favorable Survival Outcomes Compared to Conventional Colectomy
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C S Chong, C H Ng, W Sim, Zachariah Gene Wing Ow, and Kameswara Rishi Yeshayahu Nistala
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,medicine ,Surgery ,business ,Colectomy - Abstract
Introduction Conventional colectomy, and the Japanese Society for Cancer of the Colon and Rectum (JSCCR) D2 Lymphadenectomy (LND2), are the standards of care for the surgical management of colon cancer. Colectomy with complete mesocolic excision (CME) and JSCCR D3 Lymphadenectomy (LND3) are alternative, and more radical procedures, that provide greater lymph nodal clearance. However, controversy exists over the long-term survival benefits of CME/LND3 over non-CME colectomies (NCME)/LND2. Method In this study, we performed a meta-analysis to compare the survival outcomes of CME/LND3 with NCME/LND2. Medline and Embase databases were searched for articles reporting survival outcomes of both CME/LND3 and NCME/LND2, with comparisons presented using odds ratios (OR). Results Ten studies were included in this analysis. Overall and disease-free survival favored CME/LND3 (3-year OS: OR = 1.56; CI 1.22-2.00; p = 0.0004, 5-year OS: OR = 1.29; CI 1.02-1.64, p = 0.03, 3-year DFS: OR = 1.45; CI 1.12-1.88; p = 0.005, 5-year DFS: OR = 1.61; CI 1.14-2.28; p = 0.007). Overall and disease-free survival rates at five years were 79.8% and 85.9%, and 74.6% and 78.0%, in the CME/LND3 and NCME/LND2 groups respectively. Conclusions This is the first meta-analysis to demonstrate that CME/LND3 has superior long-term survival outcomes compared to NCME/LND2, hence a strong case can be made for incorporating CME/LND3 into standard care practice.
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- 2021
28. 131 Concerns of The Unheard: A Qualitative Systematic Review on The Preoperative Concerns of General Surgery Patients
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B W Z Wong, Hui Yu Tham, C S Chon, J Y J Cheng, Z H Ong, Y H Chin, C H Ng, K M Dev, and Dujeepa D. Samarasekera
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medicine.medical_specialty ,business.industry ,General surgery ,medicine ,Surgery ,business - Abstract
Aim Preoperative care is important for patients and healthcare professionals (HCPs), and greatly influences patients’ postoperative outcomes. This review aims to provide an in-depth understanding of the concerns general surgery patients have in the preoperative period and discover solutions to improve their care. Method CINAHL, Medline, PsycINFO, and Web of Science were searched, and articles related to patients’ preoperative concerns were included. Key quotes were extracted, coded, and thematically analyzed according to Thomas and Harden’s methodology. Results Three themes were generated from the 27 included articles; lead-up to surgery, the postoperative recovery process, and HCP care provision. Patients were uncertain and concerned about the impact the surgery or disease may have on them while they waited for their surgery to occur. Additionally, perceived inadequate provision of care by patients led to them doubting their HCPs’ ability, heightening their preoperative anxiety. Lastly, postoperative recovery processes were often unclear, leading to increased distress as patients wonder if they could recover from the disease and/or surgery. Conclusions Unresolved preoperative concerns increase patients’ anxiety and uncertainty, negatively affecting their postoperative recovery. A combination of individualized preoperative education and complementary therapy can be implemented by HCPs to alleviate these concerns, leading to better postoperative outcomes.
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- 2021
29. 189 Preliminary Results from an Innovative Surgical Research Group for Medical Students
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Zachariah Gene Wing Ow, Hui Yu Tham, C H Ng, N W Wong, Sneha Rajiv Jain, W H Lim, Kameswara Rishi Yeshayahu Nistala, Y H Chin, and Choon Seng Chong
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Surgical research ,medicine.medical_specialty ,business.industry ,Group (periodic table) ,Medicine ,Surgery ,Medical physics ,business - Abstract
Introduction Learning research in medical school can be daunting and difficult with many lacking appropriate guidance. Particularly, research in surgery can be difficult with most clinicians tied to long hours from clinical duties, leaving medical students lost to learn the ropes for medical research. Method We started a surgical research group in January of 2020 under a shepherd sheep model. Shepards were senior medical students who had previous experience in research and were provided resources from consultants on statistics and research designs. Thereafter, each Shepard were paired with junior medical students (sheep) and a resident to provide clinical background. Research was then carried out small teams with minimal guidance from consultants. Results To date, the group has published 11 articles (median impact factor: 2.41, range: 1.89 - 3.42), 3 articles in revision and 9 articles in review. Conclusions We provide preliminary evidence of a successful model for building medical student research in surgery. While current analysis was limited to meta-analysis and systematic review due to the availability of data, current expansion is currently underway to expand to observational studies.
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- 2021
30. 368 Perioperative Outcomes in Open versus Laparoscopic Surgery in Elderly Patients Undergoing Right Hemicolectomy
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Hui Yu Tham, S Y Lim, Y H Chin, R Wang, D J H Tan, C H Ng, C S Chong, and B J L Buan
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Laparoscopic surgery ,medicine.medical_specialty ,business.industry ,General surgery ,medicine.medical_treatment ,medicine ,Surgery ,Perioperative ,business ,Right hemicolectomy - Abstract
Introduction With the global aging population, elderly patients are increasingly undergoing colorectal surgery. This study aims to evaluate postoperative outcomes in open (OS) and laparoscopic surgery (LS) for right hemicolectomy in elderly patients. Method We retrospectively reviewed patients aged 70 and above undergoing right hemicolectomy for malignancies at our institution. Additionally, Embase and Medline databases were reviewed, and comparative meta-analysis was conducted. Results 84 patients were included in our cohort (OS = 34; LS = 50). No significant difference in anastomotic leak (AL) (OS = 4; LS = 2; p = 0.176), surgical site infection (SSI) (OS = 4; LS = 2; p = 0.216), and ileus (OS = 10; LS = 16; p = 0.801) was observed. LS was associated with decreased postoperative stay (p = 0.001). Additionally, LS had faster return of bowel function (ROBF) (p = 0.068) and resumption of diet (p = 0.147), albeit without significance. Overall survival (p = 0.062), and disease-free survival (p = 0.067) did not significantly differ between LS and OS. Pooled analysis of 463 patients yielded no significant difference in AL (OR:1.15; 95%CI: 0.17-8.01; p = 0.89), SSI (OR:0.88; 95%CI: 0.44-1.76; p = 0.71), and ileus (OR:1.42; 95%CI: 0.69 – 2.92; p = 0.35). Postoperative stay (WMD:1.90 days; 95%CI: -1.81–5.61 days; p = 0.31), and ROBF (WMD:14.49 hours; 95%CI: -4.07–33.05 hours; p = 0.13) were shortened in LS, although without significance. Conclusions LS is associated with improved functional outcomes without an increased risk of postoperative morbidity or mortality.
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- 2021
31. 19 Colectomy Rate for Moderate to Severe Ulcerative Colitis with Biologics
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Hui Yu Tham, C S Chong, M H Lee, C H Ng, J W H Koh, H H Shim, F J Fo, Z H Ong, and Y H Chin
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Moderate to severe ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,Surgery ,business ,medicine.disease ,Ulcerative colitis ,Gastroenterology ,Colectomy - Abstract
Introduction Biologics are recommended by both the ACG and ECCO community for the treatment of ulcerative colitis. Yet, current literature has yet to estimate the rate of colectomies after biologic therapy, and thus a pooled meta-analysis was conducted the rate of colectomies in 1month, 6 months, 1 year, 2years and five years after biologics. Method Medline and Embase were searched for articles examining biologics use in moderate to severe UC or acute severe UC (ASUC) from inception to 21st May 2020. Analysis of proportions were undertaken after a freeman-tukey double arcsine transformation. Results The pooled overall colectomy rates of ASUC and moderate to severe UC were 9% (CI: 4% - 14%) at one month, 18% (CI: 13% - 25%) at six months, 21% (CI:16% - 27%) at one year, 29% (CI:24% - 34%) at two years and 38% (CI:30% - 45%) at five years. Additionally, colectomy rates were consistently lower comparing between articles before and after 2010. At one-year, overall colectomy rate following infliximab use was at 25%, golimumab at 15%, vedolizumab at 14%, and adalimumab at 3%. Conclusions Colectomy rates in the era of biologics ranged from 8% to 38% and lower post-2010 showing significant improvement in management and supporting the utility of biologics in Ulcerative colitis management.
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- 2021
32. 20 Post-Operative Biologics and the Rate of Recurrence in Crohn’s Disease
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Hui Yu Tham, Sneha Rajiv Jain, C S Chong, Zachariah Gene Wing Ow, F J Foo, N W Wong, C H Ng, and W H Lim
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Crohn's disease ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General surgery ,MEDLINE ,Medicine ,Surgery ,Post operative ,business ,medicine.disease ,Endoscopy ,Recurrence risk - Abstract
Introduction Post-operative recurrence after Crohn’s surgery poses a significant challenge to clinicians with an estimated of 70-90% recurrence rate. However, with the advent of biologics, reduction of recurrence after surgery has been observed in various landmark trials. Hence, we aim to quantify the rate of recurrence with post-operative biologics. Method Searches were done on Embase and Medline database for articles using biologics for post-operative management. A single arm meta-analysis with generalized linear mixed model and Clopper-Pearson method confidence interval was applied in the synthesis of the data on six months, one year, two year and five year. Results A total of 1,864 abstracts were identified, with a final total of 24 articles and 1042 patients were included in the meta-analysis. The one-year rate of recurrence for surgical, endoscopic and clinical was 3.08% (CI: 0.74% - 11.95%), 19.93% (15.81% - 24.81%) and 13.06% (CI: 8.18% - 18.92%) respectively. Correspondingly, the five-year recurrence 16.90% (CI: 9.57% - 28.11%), 84.21% (CI: 72.35% - 91.57%), 5.60% (CI: 9.92% -23.66%) respectively. Conclusions An observed reduction in surgical rates was reduced at five years with post-operative Crohn’s disease with biologics. Biologics therapy thus can be considered as a suitable alternative for reducing post-operative recurrence in individuals with higher risk.
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- 2021
33. 295 Radiotherapy for Curative-intent Metastatic Rectal Cancer: A Systematic Review and Meta-Analysis
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J H Law, Kameswara Rishi Yeshayahu Nistala, Y Y Soon, Zachariah Gene Wing Ow, C S Chong, C H Ng, K Y Wong, and J W Yeo
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Curative intent ,Oncology ,Radiation therapy ,medicine.medical_specialty ,business.industry ,Internal medicine ,Meta-analysis ,medicine.medical_treatment ,Metastatic rectal cancer ,Medicine ,Surgery ,business - Abstract
Introduction The role and optimal regimen of radiotherapy in curative-intent treatment of metastatic rectal cancer is unclear and hence a single arm meta-analysis was performed. Method Medline, Embase and Cochrane Library databases were searched up to 16 May 2020. A Meta-analysis of binomial data was performed using a Freeman-Tukey double arcsine transformation, and pooled estimates were used to construct risk ratios and confidence intervals via the Katz-logarithmic method. Additionally, comparative meta-analysis was performed with the Mantel Haenszel model. Results 18 studies were included. Rectal pathological complete response (pCR) was observed in 14% of tumours treated with radiotherapy (n = 57/388, CI 0.07 to 0.23). Comparative meta-analysis of cohort studies showed that treatment regimens including radiotherapy were associated with higher pT1 tumour and better oncological outcomes compared to regimens without radiotherapy. Katz-logarithmic method showed that neoadjuvant radiotherapy had a higher proportion of pN0 staging (RR = 1.81, 95% CI 1.06 to 3.09, p = 0.029) and better oncological outcomes compared to adjuvant radiotherapy, and that short course radiotherapy (SCRT) had a lower proportion of pT3 tumours (RR = 0.778, 95% CI 0.609 to 0.994, p = 0.044) and similar oncological outcomes compared to long course radiotherapy (LCRT). Conclusions This study supports the evidence that radiotherapy should be used in curative intent metastatic rectal cancer.
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- 2021
34. 46 The Hidden Truth About Gender Bias in Surgery. A Systematic Review
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Shridhar Ganpathi Iyer, Sneha Rajiv Jain, M K Devi, Wen Hui Lim, C H Tai, Chloe Wong, Dujeepa D. Samarasekera, Choon Seng Chong, and Cheng H Ng
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business.industry ,Perception ,media_common.quotation_subject ,Harassment ,Gender bias ,Medicine ,Surgery ,Population health ,Symptom aggravating factors ,business ,Prejudice (legal term) ,Clinical psychology ,media_common - Abstract
Introduction Gender discrimination remains pervasive in surgery, significantly impacting current and future surgeons and population health. This study analyses the gender barriers and critical retention factors for female surgeons and trainees in surgery. Method Five electronic databases were searched till May 2020. Titles and abstracts were sieved, followed by a full text review. Data synthesis and inductive thematic analysis were conducted using the Thomas and Harden methodology. Result 14 articles were included, involving 528 participants. Four themes were generated–unfavourable working environment, male-dominated culture, societal pressures and progress towards gender equality. Females in surgery often faced harassment, disrespect and perceptions of incompetence, resulting in hostile work conditions, which were aggravated by the inadequate support and mentorship. The persistence of male-dominated cultures was observed, with females facing prejudice and exclusion from professional and social circles. Differential treatment and higher expectations of female surgeons also arose from entrenched societal pressures. Despite these, increased acceptance of motherhood and greater recognition of contributions by female surgeons were reported, indicating some progress in gendered culture. Conclusions There is a need to increase female surgical leadership and allocate resources to address the deep-rooted causes of biased surgical culture and ingrained perceptions, to achieve greater gender equality in surgery.
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- 2021
35. O52 Plasma circulating cell-free messenger RNA as a potential biomarker of melanoma
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Ita, M. I, primary, Wang, J H, additional, Fanning, N, additional, Kaar, G F, additional, Lim, C H, additional, and Redmond, H P, additional
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- 2021
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36. O3 Ex vivo normothermic machine perfusion facilitates gymnotic delivery of RNA interference therapeutics in donor kidneys
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Thompson, E R, primary, Sewpaul, A, additional, Figuereido, R, additional, Bates, L, additional, Ferdinand, J R, additional, Connelly, C M, additional, Hosgood, S A, additional, Nicholson, M L, additional, Clatworthy, M R, additional, Ali, S, additional, Wilson, C H, additional, and Sheerin, N S, additional
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- 2021
- Full Text
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37. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres
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Görgec, B, primary, Fichtinger, R S, additional, Ratti, F, additional, Aghayan, D, additional, Van der Poel, M J, additional, Al-Jarrah, R, additional, Armstrong, T, additional, Cipriani, F, additional, Fretland, Å A, additional, Suhool, A, additional, Bemelmans, M, additional, Bosscha, K, additional, Braat, A E, additional, De Boer, M T, additional, Dejong, C H C, additional, Doornebosch, P G, additional, Draaisma, W A, additional, Gerhards, M F, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, Kazemier, G, additional, Klaase, J, additional, Leclercq, W K G, additional, Liem, M S, additional, Lips, D J, additional, Marsman, H A, additional, Mieog, J S D, additional, Molenaar, Q I, additional, Nieuwenhuijs, V B, additional, Nota, C L, additional, Patijn, G A, additional, Rijken, A M, additional, Slooter, G D, additional, Stommel, M W J, additional, Swijnenburg, R J, additional, Tanis, P J, additional, Te Riele, W W, additional, Terkivatan, T, additional, Van den Tol, P M P, additional, Van den Boezem, P B, additional, Van der Hoeven, J A, additional, Vermaas, M, additional, Edwin, B, additional, Aldrighetti, L A, additional, Van Dam, R M, additional, Abu Hilal, M, additional, and Besselink, M G, additional
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- 2021
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38. Ex vivo normothermic machine perfusion facilitates gymnotic delivery of RNA interference therapeutics in donor kidneys
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Thompson, E R, primary, Sewpaul, A, additional, Figuereido, R, additional, Bates, L, additional, Ferdinand, J R, additional, Connelly, C M, additional, Hosgood, S A, additional, Nicholson, M L, additional, Clatworthy, M R, additional, Ali, S, additional, Wilson, C H, additional, and Sheerin, N S, additional
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- 2021
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39. O51 The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study
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Ita, M I, primary, Wang, J H, additional, Toulouse, A, additional, Lim, C H, additional, Fanning, N, additional, O’Sullivan, M G J, additional, Nolan, Y, additional, Kaar, G F, additional, and Redmond, H P, additional
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- 2021
- Full Text
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40. Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study
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Oba, A, primary, Wu, Y H A, additional, Lieu, C H, additional, Meguid, C, additional, Colborn, K L, additional, Beaty, L, additional, Al-Musawi, M H, additional, Davis, S L, additional, Leal, A D, additional, Purcell, T, additional, King, G, additional, Wooten, E S, additional, Fujiwara, Y, additional, Goodman, K A, additional, Schefter, T, additional, Karam, S D, additional, Gleisner, A L, additional, Ahrendt, S, additional, Leong, S, additional, Messersmith, W A, additional, Schulick, R D, additional, and Del Chiaro, M, additional
- Published
- 2021
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41. Troponin measurement for risk stratification after cytoreductive surgery
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Vacheron, C -H, primary, Lambert, A, additional, Fauvernier, M, additional, Vassal, O, additional, Wallet, F, additional, Bakrin, N, additional, Vaudoyer, D, additional, Kepenekian, V, additional, Passot, G, additional, Glehen, O, additional, Piriou, V, additional, and Friggeri, A, additional
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- 2021
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42. Multicentre study of non-surgical management of diverticulitis with abscess formation
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Janusz Lange, Daniël P. V. Lambrichts, D. C. H. E. van der Does, Simon W. Nienhuijs, Esther C. J. Consten, P. van Duijvendijk, D. Dieleman, Michael F. Gerhards, Rogier M P H Crolla, Werner A. Draaisma, Anand G. Menon, J. W. T. Dekker, Ivo A. M. J. Broeders, W. A. Bemelman, H. E. Bolkenstein, E. J. R. de Graaf, Erasmus MC other, Surgery, AGEM - Digestive immunity, and AGEM - Re-generation and cancer of the digestive system
- Subjects
Adult ,Male ,medicine.medical_specialty ,Abdominal Abscess ,Percutaneous ,Perforation (oil well) ,Risk Assessment ,Severity of Illness Index ,Diverticulitis, Colonic ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Humans ,Medicine ,Treatment Failure ,Abscess ,Colectomy ,Netherlands ,Proportional Hazards Models ,Retrospective Studies ,First episode ,business.industry ,Hazard ratio ,Retrospective cohort study ,Original Articles ,Odds ratio ,Middle Aged ,Diverticulitis ,medicine.disease ,Anti-Bacterial Agents ,Surgery ,Logistic Models ,Treatment Outcome ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Drainage ,Female ,Original Article ,030211 gastroenterology & hepatology ,business ,Follow-Up Studies - Abstract
Background Treatment strategies for diverticulitis with abscess formation have shifted from (emergency) surgical treatment to non-surgical management (antibiotics with or without percutaneous drainage (PCD)). The aim was to assess outcomes of non-surgical treatment and to identify risk factors for adverse outcomes. Methods Patients with a first episode of CT-diagnosed diverticular abscess (modified Hinchey Ib or II) between January 2008 and January 2015 were included retrospectively, if initially treated non-surgically. Baseline characteristics, short-term (within 30 days) and long-term treatment outcomes were recorded. Treatment failure was a composite outcome of complications (perforation, colonic obstruction and fistula formation), readmissions, persistent diverticulitis, emergency surgery, death, or need for PCD in the no-PCD group. Regression analyses were used to analyse risk factors for treatment failure, recurrences and surgery. Results Overall, 447 patients from ten hospitals were included (Hinchey Ib 215; Hinchey II 232), with a median follow-up of 72 (i.q.r. 55–93) months. Most patients were treated without PCD (332 of 447, 74·3 per cent). Univariable analyses, stratified by Hinchey grade, showed no differences between no PCD and PCD in short-term treatment failure (Hinchey I: 22·3 versus 33 per cent, P = 0·359; Hinchey II: 25·9 versus 36 per cent, P = 0·149) or emergency surgery (Hinchey I: 5·1 versus 6 per cent, P = 0·693; Hinchey II: 10·4 versus 15 per cent, P = 0·117), but significantly more complications were found in patients with Hinchey II disease undergoing PCD (12 versus 3·7 per cent; P = 0·032). Multivariable analyses showed that treatment strategy (PCD versus no PCD) was not independently associated with short-term treatment failure (odds ratio (OR) 1·47, 95 per cent c.i. 0·81 to 2·68), emergency surgery (OR 1·29, 0·56 to 2·99) or long-term surgery (hazard ratio 1·08, 95 per cent c.i. 0·69 to 1·69). Abscesses of at least 3 cm in diameter were associated with short-term treatment failure (OR 2·05, 1·09 to 3·86), and abscesses of 5 cm or larger with the need for surgery during short-term follow-up (OR 2·96, 1·03 to 8·13). Conclusion The choice between PCD with antibiotics or antibiotics alone as initial non-surgical treatment of Hinchey Ib and II diverticulitis does not seem to influence outcomes.
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- 2019
43. Prognostic characteristics of duodenal gastrointestinal stromal tumours
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Zhang, Q., Shou, C.-H., Yu, J.-R., Yang, W.-L., Liu, X.-S., Yu, H., Gao, Y., Shen, Q.-Y., and Zhao, Z.-C.
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- 2015
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44. Fowlerʼs syndrome of the anorectum?: O132
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Shamsiddinova, A., Horrocks, E. J., Mackenzie, H., Scott, S. M., and Knowles, C. H.
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- 2015
45. Long-term outcomes of sacral nerve stimulation for faecal incontinence
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Altomare, D. F., Giuratrabocchetta, S., Knowles, C. H., Muñoz Duyos, A., Robert-Yap, J., and Matzel, K. E.
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- 2015
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46. Randomized clinical trial of sacral versus percutaneous tibial nerve stimulation in patients with faecal incontinence
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Thin, N. N., Taylor, S. J. C., Bremner, S. A., Emmanuel, A. V., Hounsome, N., Williams, N. S., and Knowles, C. H.
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- 2015
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47. Effect of local injection of mesenchymal stem cells on healing of sutured gastric perforation in an experimental model
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Liu, L., Chiu, P. W. Y., Lam, P. K., Poon, C. C. Y., Lam, C. C. H., Ng, E. K. W., and Lai, P. B. S.
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- 2015
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48. Surgical innovation
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Dejong, C. H. C. and Earnshaw, J. J.
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- 2015
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49. Survival after neoadjuvant chemoradiotherapy and oesophagectomy versus definitive chemoradiotherapy for patients with oesophageal squamous cell carcinoma
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Hui Shan Chen, H. S. Chen, Shiao Chi Wu, C.‐H. Lin, W.‐H. Hung, C.‐L. Huang, and B.‐Y. Wang
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Adult ,Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Taiwan ,030230 surgery ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Propensity Score ,Neoadjuvant therapy ,Aged ,business.industry ,Hazard ratio ,Chemoradiotherapy ,Definitive chemoradiotherapy ,Middle Aged ,Cancer registry ,Esophagectomy ,Survival Rate ,Treatment Outcome ,Propensity score matching ,Cohort ,Female ,Surgery ,Esophageal Squamous Cell Carcinoma ,business - Abstract
Background Whether there is a difference in survival after neoadjuvant chemoradiotherapy plus surgery (CRT-S) compared with definitive chemoradiotherapy (dCRT) in patients with locally advanced oesophageal squamous cell carcinoma (SCC) remains controversial. Methods Patients with SCC who underwent curative treatment from 2008 to 2014 were identified from the Taiwan Cancer Registry. Propensity score matching was undertaken to balance pretreatment clinical variables. Overall survival was compared between patients undergoing CRT-S or dCRT. Univariable and multivariable analyses were performed to identify prognostic factors for overall survival. Results A total of 5832 patients with clinical stage II and III oesophageal SCC receiving CRT-S (1754) or dCRT (4078) were included. After propensity score matching, each group included 1661 patients. The 3-year overall survival rate for patients treated with CRT-S was 41·1 per cent compared with 17·9 per cent for those who had dCRT (P < 0·001). In multivariable analysis, treatment modality was an independent prognostic factor in the overall cohort before propensity score matching: hazard ratio 0·45 (95 per cent c.i. 0·40 to 0·51) for CRT-S versus dCRT (P < 0·001). In separate analyses of patients with clinical stage II and those with stage III disease, CRT-S was associated with significantly better overall survival than dCRT. Conclusion Neoadjuvant chemoradiotherapy and oesophagectomy is associated with better overall survival than dCRT in patients with stage II and III oesophageal SCC.
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- 2018
50. Adverse outcomes after surgery in patients with previous stroke: Resultados adversos después de la cirugía en pacientes con ictus previo
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Liao, C. C., Chang, P. Y., Yeh, C. C., Hu, C. J., Wu, C. H., and Chen, T. L.
- Published
- 2014
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