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During the period of COVID-19, the number of residents infected in urban communities continued to rise, implying that most of the current building layouts can't effectively resist the spread of infectious diseases, and the outbreak of COVID-19 has led to the need of changes for the current building environment. Therefore, the epidemic prevention should be considered in the residential building design, and the health design of residential community should be carried out from the perspective of epidemic prevention. In order to improve the ability of epidemic prevention of residential buildings and deal with the sudden pandemic and influenza in the post-epidemic era, a Healthy Assessment System for Residential Building Epidemic Prevention (HASRBEP) was developed according to the epidemic impact on residential buildings, the design and measures of epidemic prevention for residential buildings and the Chinese Assessment standard for healthy building (T/ASC 02–2016). Both entropy weight method and expert scoring method were used to determine the specific weight of the index. The HASRBEP includes control item assessment, preliminary assessment and extension assessment. The newly developed HASRBEP was used to assess the residential buildings of the Yulongzhuang Building Community located in Quanzhou, Fujian Province, China. The results show that the HASRBEP can be used to guide the health and epidemic prevention design of residential buildings. • The assessment index system of healthy building is reconstructed and the assessment contents of healthy building are enriched. • The index weight system of healthy assessment of residential building is reestablished. • A multi-level extension health assessment model is newly constructed. • The HASRBEP can be used to guide the health and epidemic prevention design of residential buildings. [ABSTRACT FROM AUTHOR]