1. [Description of a peculiar form of Hodgkin's disease associated with Epstein-Barr virus infection].
- Author
-
Elira Dokekias A, Koko I, Atipo Galiba FO, and Martin A
- Subjects
- Acyclovir therapeutic use, Adolescent, Anemia, Hemolytic, Autoimmune diagnosis, Antibiotics, Antineoplastic administration & dosage, Antineoplastic Agents, Alkylating administration & dosage, Antineoplastic Agents, Phytogenic administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Antiviral Agents therapeutic use, Autoantibodies immunology, Bleomycin administration & dosage, Bleomycin therapeutic use, Dacarbazine administration & dosage, Dacarbazine therapeutic use, Doxorubicin administration & dosage, Doxorubicin therapeutic use, Humans, Immunoglobulin G immunology, Male, Vinblastine administration & dosage, Vinblastine therapeutic use, Epstein-Barr Virus Infections diagnosis, Hodgkin Disease virology, Tumor Virus Infections diagnosis
- Abstract
The authors report a peculiar form of Hodgkin's disease that is associated with Epstein-Barr virus infection. A 16-year-old patient was admitted for an autoimmune haemolytic anaemia associated with IgG auto-immune antibodies, linked to general clinical complications, cervical adenopathies and splenomegalia. The patient underwent hemicavectomy that was not histologically investigated. The ganglionar exeresis helped to establish the histological diagnosis of Hodgkin's disease, classic form with nodular sclerosis. Tumour cells were CD30 CD15 positive and neighbouring lymphoid cells were CD3 and CD20 positive. In situ hybridation allowed the detection of Epstein-Barr virus in tumour cells. Under ABVD chemotherapy supplemented with acyclovir and initial corticotherapy, mid-treatment evolution appears to be favourable. This observation is consistent with the hypothesis that tumour cells are of B cell origin during Hodgkin's disease, together with the involvement of Epstein-Barr virus in lymphomagenesis.
- Published
- 2007