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Your search keyword '"F, Duigou"' showing total 4 results
Start Over Author "F, Duigou" Journal bulletin du cancer
4 results on '"F, Duigou"'

1. [Flow cytometry in ORL cancers]

Author

J J, Michels, J P, Rame, D, de Raucourt, J, Marnay, F, Duigou, J, Macé-Lesec'h, M, Henry-Amar, and A M, Mandard

Subjects
Adult, Aged, 80 and over, Male, Ploidies, DNA, Neoplasm, Middle Aged, Flow Cytometry, Prognosis, Sensitivity and Specificity, S Phase, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Humans, Female, Prospective Studies, Aged, Neoplasm Staging
Abstract

The possibility to perform flow cytometry was examined in a series of 167 patients with primary untreated head and neck carcinoma referred to our Institution from February 1989 to January 1992. In all cases, flow cytometry was carried out on frozen tumour samples. The Cox model was used including age, tumour size, nodal status on clinical assessment, topography, treatment, malignancy grade, S phase fraction and ploidy as independent variables and overall survival as dependent variable. In this study, ploidy could be assessed in only 73% of cases and S phase fraction and G2M in 65% of the population studied. No correlation could be evidenced between ploidy or SPF with other clinical, pathologic characteristics or clinical outcome. We conclude that flow cytometry should remain a research tool until the method has proved to be relevant in clinical routine, and until the yield of the technique can be improved.

Published
1997

2. [Automation of the cytometric analysis of the DNA content of solid tumors]

Author

P, Herlin, E, Masson, F, Duigou, B, Plancoulaine, J P, Signolle, A M, Mandard, F, Angot, D, Deman, P, Belhomme, J B, Joret, T, Datry, O, Rougereau, and D, Bloyet

Subjects
Cell Nucleus, Ploidies, Image Processing, Computer-Assisted, Humans, Reproducibility of Results, Breast Neoplasms, Female, DNA, Neoplasm, Flow Cytometry, Software
Abstract

An automatic machine, dedicated to solid tumor DNA ploidy quantitation has been built in order to provide pathologists with a tool usable in clinical practice. Main efforts were focused on an automation of each step of the analysis and on an elimination of any subjective choice, while preserving the quality of measurement. As the software is independent of the machine architecture, it offers performances which increase in parallel with the rapid evolution of the computers. An illustration of the various functionalities of the automaton is proposed through the study of deparaffined breast cancer samples.

Published
1997

3. [Flow cytometry in ORL cancers].

Author

Michels JJ, Rame JP, de Raucourt D, Marnay J, Duigou F, Macé-Lesec'h J, Henry-Amar M, and Mandard AM

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Female, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Humans, Male, Middle Aged, Neoplasm Staging, Ploidies, Prognosis, Prospective Studies, S Phase, Sensitivity and Specificity, Carcinoma, Squamous Cell genetics, DNA, Neoplasm analysis, Flow Cytometry, Head and Neck Neoplasms genetics
Abstract

The possibility to perform flow cytometry was examined in a series of 167 patients with primary untreated head and neck carcinoma referred to our Institution from February 1989 to January 1992. In all cases, flow cytometry was carried out on frozen tumour samples. The Cox model was used including age, tumour size, nodal status on clinical assessment, topography, treatment, malignancy grade, S phase fraction and ploidy as independent variables and overall survival as dependent variable. In this study, ploidy could be assessed in only 73% of cases and S phase fraction and G2M in 65% of the population studied. No correlation could be evidenced between ploidy or SPF with other clinical, pathologic characteristics or clinical outcome. We conclude that flow cytometry should remain a research tool until the method has proved to be relevant in clinical routine, and until the yield of the technique can be improved.

Published
1997

4. [Automation of the cytometric analysis of the DNA content of solid tumors].

Author

Herlin P, Masson E, Duigou F, Plancoulaine B, Signolle JP, Mandard AM, Angot F, Deman D, Belhomme P, Joret JB, Datry T, Rougereau O, and Bloyet D

Subjects
Breast Neoplasms chemistry, Breast Neoplasms pathology, Cell Nucleus chemistry, Cell Nucleus pathology, Female, Flow Cytometry, Humans, Ploidies, Reproducibility of Results, DNA, Neoplasm analysis, Image Processing, Computer-Assisted methods, Software
Abstract

An automatic machine, dedicated to solid tumor DNA ploidy quantitation has been built in order to provide pathologists with a tool usable in clinical practice. Main efforts were focused on an automation of each step of the analysis and on an elimination of any subjective choice, while preserving the quality of measurement. As the software is independent of the machine architecture, it offers performances which increase in parallel with the rapid evolution of the computers. An illustration of the various functionalities of the automaton is proposed through the study of deparaffined breast cancer samples.

Published
1997

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