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Objective: Burn trauma is a life-threatening incident that may be accompanied by several risk factors that increase morbidity and mortality. Drug abuse is one of the lifestyle dangers on the rise globally and can have an impact on the outcomes of burn injuries. This study aimed to evaluate the effect of drug abuse on the clinical outcomes of adult burn patients who were admitted to a burn center in the North of Iran., Methods: This retrospective cross-sectional study included adult burn patients who were referred to Velayat Hospital, between March 1, 2021, and March 20, 2022. The hospital information system (HIS) was used to select patients with a history of drug use and then were compared with burn victims who had never used drugs before. In both groups, demographic information, the cause of the burn, the comorbid diseases, total body surface area, length of stay, and outcomes were collected and recorded for both groups., Results: This study included 114 inpatients, 90 of whom (78.95%) were men. The mean age of the patients was 43±15 years. The mean length of hospitalization in the drug-user group was significantly higher than in the non-drug abuse group ( p =0.004). The drug abuse group had significantly higher rates of comorbid diseases ( p =0.021), inhalation injury ( p <0.001), mortality ( p =0.002), and pneumonia ( p <0.001). However, there were no statistically significant differences in the Infection and Sir's rates ( p =0.583) between the groups., Conclusion: Drug abuse is a risk factor in adult burn patients, which can affect the length of stay and burn-related morbidities., Competing Interests: None of the authors has any personal or financial conflicts of interest.