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We studied biological rhythms of immunological parameters and absorption and digestive activities of neutrophils and monocytes in women during the menstrual cycle. Circadian rhythms of phagocytosis were evaluated. The phagocytic system was characterized by highest activity during ovulation and early luteal phase of the menstrual cycle accompanied by physiological immunosuppression. It was shown that macrophages determine the spatial and temporal organization of specific and nonspecific resistance in women. We evaluated phases of the menstrual cycle optimal for studying rhythms of the immune system and phagocytosis.

Biorhythms of iron metabolism in healthy women and patients with iron deficiency were studied during lactation. Healthy nursing women were characterized by circadian variations in the concentrations of iron, alpha-tocopherol, and malonic dialdehyde in breast milk. Diurnal variations in iron concentration, antioxidant potential, and lipid peroxidation in breast milk depended on iron metabolism in nursing women. Iron deficiency was accompanied by a decrease in the concentrations of alpha-tocopherol and iron, increase in malonic dialdehyde content, and suppression of circadian variations in these parameters in breast milk.

Biorhythms of absorption capacity of neutrophils and monocytes were studied in women with latent iron deficiency. We revealed disorders in circadian organization of the mononuclear phagocyte system and decreased reserve capacity of nonspecific organism's resistance against the background of tissue iron deficiency. Informative value of desynchronosis in circadian structure of the phagocyte absorption capacity as the early marker of prelatent iron deficiency was established.

We studied biological rhythms of immunological parameters and absorption and digestive activities of neutrophils and monocytes in women during the menstrual cycle. Circadian rhythms of phagocytosis were evaluated. The phagocytic system was characterized by highest activity during ovulation and early luteal phase of the menstrual cycle accompanied by physiological immunosuppression. It was shown that macrophages determine the spatial and temporal organization of specific and nonspecific resistance in women. We evaluated phases of the menstrual cycle optimal for studying rhythms of the immune system and phagocytosis.

Biorhythms of absorption capacity of neutrophils and monocytes were studied in women with latent iron deficiency. We revealed disorders in circadian organization of the mononuclear phagocyte system and decreased reserve capacity of nonspecific organism's resistance against the background of tissue iron deficiency. Informative value of desynchronosis in circadian structure of the phagocyte absorption capacity as the early marker of prelatent iron deficiency was established.

A biologically active RNA which, when transferred to chick embryonic cells, produced an antiviral state in them, was isolated from cultures of chick embryonic cells treated with interferon. The level of reproduction of vesicular stomatitis virus in these cells was 2–30% of the level of reproduction observed in cells treated with control RNA. Maximal activity of the experimental RNA was observed after exposure to interferon for 3 h.