1. Effect of enkephalin and cimetidine on the onset and course of duodenal ulcers in rats
- Author
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Vinogradov Va, Smagin Vg, and Polonskiĭ Vm
- Subjects
Ulcer healing ,medicine.medical_specialty ,Increased serum gastrin ,Enkephalin ,business.industry ,digestive, oral, and skin physiology ,General Medicine ,digestive system diseases ,General Biochemistry, Genetics and Molecular Biology ,Duodenal ulcer ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Medicine ,Cysteamine ,Cimetidine ,business ,hormones, hormone substitutes, and hormone antagonists ,Gastrin ,medicine.drug - Abstract
A study was made of the effect of a synthetic enkephalin analog and cimetidinee on experimental duodenal ulcer in rats induced by cysteamine administration. The ulcers were demonstrated to heal within 4 weeks. It was noted that ulcer occurrence was preceded by the increased serum gastrin level. Administration to rats of the enkephalin analog accelerated ulcer healing to a greater extent than that of cimetidin. It is suggested that one of the mechanisms of enkephalin analog protective action might involve the prevention of the gastrin increased level.
- Published
- 1982
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