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Your search keyword '"M. A. Plyushch"' showing total 3 results
Start Over Author "M. A. Plyushch" Journal bulletin of experimental biology and medicine
3 results on '"M. A. Plyushch"'

1. Markers of Myocardial Damage in Children of the First Year of Life with Congenital Heart Disease in the Early Period after Surgery with Cardioplegic Anoxia

Author

M. G. Plyushch, E. F. Kozar, R. R. Movsesyan, A. E. Popov, O. I. Kulaga, N. N. Samsonova, and L. A. Bokeriya

Subjects
Heart Defects, Congenital, medicine.medical_specialty, Heart disease, Period (gene), Cardiac marker, Myocardial Ischemia, First year of life, General Biochemistry, Genetics and Molecular Biology, Troponin T, Internal medicine, medicine, Creatine Kinase, MB Form, Humans, Hypoxia, biology, business.industry, Infant, General Medicine, Perioperative, medicine.disease, Cardiac surgery, Surgery, ROC Curve, Area Under Curve, Heart Arrest, Induced, biology.protein, Cardiology, Creatine kinase, business, Biomarkers
Abstract

We measured the level of cardiac markers (high-sensitivity troponin T and MB fraction of creatine kinase) in children of the first year of life with congenital heart disease in the perioperative period. After cardiac surgery, plasma levels of the above markers exceed the reference limits in the examined children. The diagnosis of myocardial ischemia using biochemical markers in the postoperative period is possible only by dynamic monitoring of the cardiac marker level. The preoperative concentration of high-sensitivity troponin T in children of the first year of life with congenital heart disease can be regarded as a predictor of postoperative complications.

Published
2015

2. The use angiogenesis stimulators for the treatment of chronic ischemia of lower extremities

Author

L. A. Bokeriya, V. S. Arakaelyan, N. D. Nisnevich, O. A. Demidova, D. I. Kolesnik, M. G. Plyushch, and M. V. Eremeeva

Subjects
Adult, Male, medicine.medical_specialty, Angiogenesis, Genetic enhancement, Cell- and Tissue-Based Therapy, Ischemia, General Biochemistry, Genetics and Molecular Biology, Microcirculation, chemistry.chemical_compound, Antigens, CD, Humans, Medicine, AC133 Antigen, Sf 36 questionnaire, Aged, Glycoproteins, Aged, 80 and over, Leg, medicine.diagnostic_test, business.industry, Angiography, Genetic Therapy, General Medicine, Middle Aged, medicine.disease, Surgery, Vascular endothelial growth factor, chemistry, Anesthesia, Chronic Disease, Angiogenesis Inducing Agents, Female, Transcutaneous oxygen, Peptides, business
Abstract

We present the results of treatment of chronic ischemia of the lower extremities (distal form) with angiogenesis stimulators, autologous endothelioblast precursors (CD133+) and gene preparation of vascular endothelial growth factor VEGF165 (angiostimulin). Good clinical effect was attained in all patients, which was confirmed instrumentally 1, 3, and 6 months after administration of the stimulant: transcutaneous oxygen tension on the foot, index of malleolar pressure, and walking duration increased, parameters of microcirculation improved, the number of newly formed collateral arteries increased (angiography findings), quality of life improved (SF 36 questionnaire), and parameters of coagulogram also improved. The maximum positive dynamics was observed by month 3 of the study.

Published
2007

3. Experimental study of the effects of sodium ion concentrations on the function of the myocardium exposed to cardioplegic ischemia

Author

M. G. Plyushch, Alexander A. Boldyrev, N. V. Kalaeva, O. I. Kulaga, R. R. Movsesyan, G. A. Bledzhyants, D. N. Egorov, L. A. Bokeriya, A. E. Popov, and E. F. Kozar

Subjects
Cardiac function curve, Male, medicine.medical_specialty, Sodium, Ischemia, chemistry.chemical_element, General Biochemistry, Genetics and Molecular Biology, Ion, Internal medicine, Extracellular fluid, medicine, Animals, Rats, Wistar, Electrolyte composition, Chromatography, Dose-Response Relationship, Drug, Chemistry, Myocardium, Extracellular Fluid, General Medicine, Cardioplegic solutions, medicine.disease, Rats, Cardiology, Heart Arrest, Induced, Intracellular
Abstract

A new cardioplegic solution based on three natural dipeptides was developed and introduced at the Laboratory of Cardioplegia, A. N. Bakulev Research Center of Cardiovascular Surgery. The electrolyte composition of the solution corresponded to the category of intracellular cardioplegic solutions. The results of 60 experiments on isolated rat hearts were analyzed for choosing the optimal concentration of sodium ions (35, 60, or 80 mmol/liter). The composition of the studied cardioplegic solutions was selected by ion concentrations in the intra- and extracellular fluid. Earlier and most effective recovery of cardiac function with minimum rhythm and conductivity disorders was observed in the group treated with cardioplegic solution with sodium ion concentration of 60 mmol/liter.

Published
2012

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