1. Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis.
- Author
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Blinova EA, Zinnatova EV, Barkovskaya MSh, Borisov VI, Sizikov AE, Kozhevnikov VS, Rubtsov NB, and Kozlov VA
- Subjects
- Adult, Arthritis, Rheumatoid genetics, Case-Control Studies, Female, Humans, Male, Middle Aged, Arthritis, Rheumatoid pathology, Chromosomes, Human genetics, Telomere genetics, Telomere Homeostasis
- Abstract
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
- Published
- 2016
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