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1. Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells.

Author

Bozhenko VK, Ivanov AV, Kulinich TM, Smirnov VP, Shishkin AM, and Solodky VA

Subjects
Cell Line, Tumor, Cell Survival radiation effects, Dose-Response Relationship, Radiation, Humans, Jurkat Cells, Lymphocytes pathology, Necrosis pathology, Primary Cell Culture, Apoptosis radiation effects, Gamma Rays, Lymphocytes radiation effects
Abstract

We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of "early" apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.

Published
2019
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