1. Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians.
- Author
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Lukyanova SO, Artemyeva OV, Strazhesko ID, Nasaeva ED, Grechenko VV, and Gankovskaya LV
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Young Adult, Aging genetics, Cytokines metabolism, Nonagenarians, Frailty, Interleukin-10 genetics, Interleukin-1beta genetics, Toll-Like Receptor 2 genetics
- Abstract
The expression of the gene of pattern recognition receptor TLR2, proinflammatory cytokine IL-1β, and anti-inflammatory cytokine IL-10 was analyzed in the peripheral blood of nonagenarians (n=219; mean age 92.1 years, 77 men and 142 women) in comparison with healthy young donors (n=24; mean age 22.5 years, 16 women and 8 men). Nonagenarians were interviewed, medical records were analyzed, and a comprehensive geriatric assessment was performed according to the Clinical Guidelines on Frailty. The level of gene expression was determined by real-time PCR. The participation of inflammatory mechanisms in the immunosenescence was revealed. It was shown that increased expression of IL1B and TLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression of IL10 gene can be considered as a factor of successful aging in nonagenarians., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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