1. Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative
- Author
-
V. A. Otellin, V. K. Akulova, Natalia Ordyan, and V. I. Mironova
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Motor Activity ,General Biochemistry, Genetics and Molecular Biology ,gamma-Aminobutyric acid ,Reflex, Righting ,03 medical and health sciences ,Grip strength ,0302 clinical medicine ,Pregnancy ,Internal medicine ,Forelimb ,Animals ,Humans ,Medicine ,Juvenile ,Rats, Wistar ,gamma-Aminobutyric Acid ,Behavior, Animal ,Hand Strength ,business.industry ,Neonatal encephalopathy ,Mental Disorders ,General Medicine ,Hypoxia (medical) ,medicine.disease ,Rats ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,Animals, Newborn ,Hypoxia-Ischemia, Brain ,Reflex ,Premature Birth ,Female ,Righting reflex ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
We studied the effects of acute normobaric hypoxia on postnatal day 2 (model of preterm pregnancy) on reflex activity and behavior of juvenile male Wistar rats and the possibility of correction of behavioral deficit by administration of GABA derivative Salifen after hypoxia. It is shown, that perinatal hypoxia impaired righting reflex and forelimb grip strength and increased motor activity in juvenile male rats. Administration of Salifen for 14 days in a dose of 15 mg/kg improved reflex activity and behavior of rats, which indicates the prospect of further study of the therapeutic efficacy of this drug on models of neonatal encephalopathy.
- Published
- 2017