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Your search keyword '"Vladimir A. Kulchitsky"' showing total 2 results
Start Over Author "Vladimir A. Kulchitsky" Journal bulletin of experimental biology and medicine
2 results on '"Vladimir A. Kulchitsky"'

1. Proliferation and Survival of Rat C6 Glioma Culture in the Presence of Implants Coated with Modified Carbon-Based Films

Author

A. N. Chernov, L. V. Pozdniak, N. M. Chekan, N. M. Beliauski, G. G. Poljanskaya, A. I. Gordienko, Vladimir A. Kulchitsky, and V. V. Akulich

Subjects
Silver, Proliferation index, Diamond-like carbon, Cell Survival, Metal Nanoparticles, chemistry.chemical_element, Biocompatible Materials, General Biochemistry, Genetics and Molecular Biology, Silver nanoparticle, Cell Line, Tumor, Glioma, medicine, Animals, Cell Proliferation, Titanium, Chemistry, Cell growth, Metallurgy, technology, industry, and agriculture, Titanium alloy, General Medicine, medicine.disease, Carbon, Rats, Nuclear chemistry
Abstract

The survival of rat C6 glioma decreased in the presence of implants from VT-16 titanium alloy. Diamond-like carbon coating of VT-16 alloy slightly increased cell death on day 5 of the experiment (39.9+/-2.1%). The percentage of dead C6 glioma cells inside titanium rings with diamond-like carbon coating, incorporating up to 3.5 atom.% Ag nanoparticles, was 53.7+/-4.3% on day 5 of culturing, while after doping to 6.7 atom.% Ag cell death reached 66.7+/-3.2% (p0.05). The maximum toxic effect towards C6 glioma was detected in the specimens coated with diamond-like film with silver nanoparticles.

Published
2009

2. Generation of excitatory postsynaptic potentials in the hippocampus after functional modification of glycosaminoglycans

Author

N. V. Yakubovich, Pavel G. Molchanov, S. G. Pashkevich, A. A. Emel’janova, A. A. Denisov, Yu. S. Garkun, and Vladimir A. Kulchitsky

Subjects
Male, Population, Hyaluronoglucosaminidase, Hippocampus, Stimulation, Biology, Hippocampal formation, Neurotransmission, Models, Biological, Synaptic Transmission, General Biochemistry, Genetics and Molecular Biology, Organ Culture Techniques, medicine, Animals, Rats, Wistar, education, Glycosaminoglycans, education.field_of_study, Nervous tissue, Excitatory Postsynaptic Potentials, General Medicine, Rats, Electrophysiology, medicine.anatomical_structure, Excitatory postsynaptic potential, Neuroscience, Signal Transduction
Abstract

Experiments on hippocampal slices form 4-week-old rats (n=28) showed that addition of lidase (1.0 and 10.0 U/ml) to the perfusion solution (artificial cerebrospinal fluid) was accompanied by the impaired generation or blockade of excitatory postsynaptic potentials and population spikes in the hippocampal CA1 region during stimulation of Schaffer collaterals. Removal of lidase from this solution normalized the amplitude of evoked responses. Hence, lidase in these concentrations produced a reversible effect on synaptic transmission. Our results indicate that structure and function of glycosaminoglycans in the extracellular matrix determine signal transduction in the nervous tissue.

Published
2008

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