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This research paper presents a comprehensive historical analysis of long-acting antipsychotic medications (LAI) tracing their evolution from the early days of oral formulations to the current landscape of sustained-release injectables. The study aims to provide insight into the chronological development, milestones, and paradigm shifts that have shaped the trajectory of LAIs in the treatment of psychotic disorders. The exploration commences with an examination of the pioneering efforts that led to the conceptualization of psychiatric medication, shedding light on the initial challenges faced in achieving therapeutic efficacy with sustained drug delivery. Through an in-depth historical lens, the paper highlights pivotal moments in the development of LAIs, including the advent of depot formulations and the subsequent refinement of pharmacokinetic properties for optimal symptom control. The analysis unfolds by delineating key milestones in the timeline of LAIs, incorporating landmark studies, regulatory approvals, and technological innovations that have influenced their adoption in psychiatric practice. A focus is placed on the societal and clinical impact of LAIs, emphasizing their role in addressing treatment non-adherence and reducing the burden of relapse. Furthermore, the paper explores the paradigmatic shift in the perception of LAIs, moving from skepticism to widespread acceptance within the psychiatric community. The historical context is used to illuminate the socio-cultural factors that have influenced the utilization of LAIs, including changing attitudes toward mental health treatment, patient empowerment, and evolving healthcare policies. In conclusion, this historical analysis provides a nuanced understanding of the journey of LAIs, underscoring their transformation from experimental formulations to indispensable tools in the contemporary psychiatric armamentarium. By tracing the historical tapestry of LAIs, this research contributes to a deeper appreciation of their evolution, offering valuable insights for clinicians, researchers, and policymakers engaged in the ongoing discourse on the role of long-acting antipsychotic medications in the holistic management of psychotic disorders. [ABSTRACT FROM AUTHOR]