1. A novel, reverse-phase-shifting, thermoreversible foaming hydrogel containing antibiotics for the treatment of thermal burns in a swine model - A pilot study.
- Author
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Donaldson RI, Armstrong JK, Buchanan OJ, Graham TL, Cambridge JS, Cristerna NN, Goldenberg D, Tanen CDA, Fisher TC, Tolles J, Burns CJ, and Ross JD
- Subjects
- Animals, Pilot Projects, Swine, Anti-Infective Agents, Local therapeutic use, Hydrogels therapeutic use, Bandages, Wound Infection drug therapy, Wound Infection prevention & control, Random Allocation, Burns drug therapy, Burns microbiology, Burns pathology, Silver Sulfadiazine therapeutic use, Necrosis, Disease Models, Animal, Wound Healing drug effects, Anti-Bacterial Agents therapeutic use
- Abstract
Background: This study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence of concomitant bacterial inoculation., Methods: Eight equal burn wounds were created on six Yorkshire swine. Half the wounds were randomized to post-burn bacterial inoculation. Wounds were subsequently randomized to three treatments groups: no intervention, CI-PRJ012, or silver sulfadiazine cream. At study end, a blinded pathologist evaluated wounds for necrosis and bacterial colonization., Results: When comparing CI-PRJ012 and silver sulfadiazine cream to no treatment, both agents significantly reduced the amount of necrosis and bacteria at 7 days after wound creation (p < 0.01, independently for both). Further, CI-PRJ012 was found to be significantly better than silver sulfadiazine (p < 0.02) in reducing bacterial colonization. For wound necrosis, no significant difference was found between silver sulfadiazine cream and CI-PRJ012 (p = 0.33)., Conclusions: CI-PRJ012 decreases necrosis and bacterial colonization compared to no treatment in a swine model. CI-PRJ012 appeared to perform comparably to silver sulfadiazine. CI-PRJ012, which is easily removed with the application of room-temperature water, may provide clinical advantages over silver sulfadiazine., Competing Interests: Declaration of Competing Interest TLG and JDR have no conflicts of interest to declare. CJB, JT, and DAT were paid consultants on this project. RID, TCF, OJB, JSC, DG, NNC, and JKA are employees of Critical Innovations. RID, TCF, OJB, JSC, NNC, and JKA are inventors of CI-PRJ012 technology, with related intellectual property rights., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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