1. Coagulation defects in experimental hepatic injury in the dog.
- Author
-
Osbaldiston GW and Hoffman MW
- Subjects
- Adrenal Cortex Hormones pharmacology, Animals, Blood Coagulation Disorders pathology, Blood Coagulation Factors, Blood Coagulation Tests, Blood Transfusion, Dogs, Liver drug effects, Liver enzymology, Mitochondria, Liver drug effects, Blood Coagulation Disorders etiology, Liver injuries
- Abstract
Alteration in activity of blood coagulation factors in dogs with acute hepatic injury caused by oral carbon tetrachloride dosing was studied. Coagulation Factors II, VII and IX were dramatically reduced within 48 hours but recovered to normal in the next five days. Because surgery is rarely performed on dogs with hepatic necrosis, the use of fresh whole blood tranfusion to improve the coagulation defect in hepatic injury was also studied. Transfusion was found to have only a temporary beneficial effect.
- Published
- 1971