1. Pathways of carbohydrate metabolism in Mycobacterium tuberculosis H37Rv
- Author
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T.A. Venkitasubramanian, N. Jayanthi Bai, P. Suryanarayana Murthy, and M. Ramachandra Pai
- Subjects
chemistry.chemical_classification ,biology ,Immunology ,General Medicine ,Carbohydrate metabolism ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Microbiology ,Enzyme ,chemistry ,Biochemistry ,Mycobacterium tuberculosis H37Rv ,Genetics ,Molecular Biology ,Mycobacterium - Abstract
Radiorespirometric studies using glucose labelled at 1, 2, 3–4, and 6 positions and enzymatic studies were conducted to determine the primary pathways of glucose dissimilation in Mycobacterium tuberculosis H37Rv. The pattern of 14CO2 recovery was C3−4 > C1 > C6 = C2. The Embden–Meyerhof pathway was found to be the predominant pathway for glucose oxidation, operative to the extent of 94%. The pentose phosphate pathway accounted for the remaining 6%. Maximum incorporation of 14C into cellular components was from C2 and C6 labelled glucose.
- Published
- 1975
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