5 results on '"Cochrane DD"'
Search Results
2. Management of optic chiasmatic/hypothalamic astrocytomas in children.
- Author
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Steinbok P, Hentschel S, Almqvist P, Cochrane DD, and Poskitt K
- Subjects
- Adolescent, Child, Child, Preschool, Female, Glioma diagnosis, Glioma mortality, Glioma pathology, Humans, Hypothalamic Neoplasms diagnosis, Hypothalamic Neoplasms mortality, Hypothalamic Neoplasms pathology, Infant, Male, Optic Chiasm pathology, Optic Nerve Neoplasms diagnosis, Optic Nerve Neoplasms mortality, Optic Nerve Neoplasms pathology, Retrospective Studies, Treatment Outcome, Glioma therapy, Hypothalamic Neoplasms therapy, Optic Nerve Neoplasms therapy
- Abstract
Objective: The management of optic chiasmatic gliomas is controversial, partly related to failure to separate out those tumors involving the optic chiasm only (chiasmatic tumors) from those also involving the hypothalamus (chiasmatic/hypothalamic tumors). The purpose of this study was: (i) to analyze the outcomes of chiasmatic and chiasmatic/hypothalamic tumors separately; and (ii) to determine the appropriateness of recommending radical surgical resection for the chiasmatic/hypothalamic tumors., Methods: A retrospective chart review of all newly diagnosed tumors involving the optic chiasm from 1982-1996 at British Columbia's Children's Hospital was performed., Results: There were 32 patients less than 16 years of age, 14 with chiasmatic and 18 with chiasmatic/hypothalamic astrocytomas, with an average duration of follow-up of 5.8 years and 6.3 years, respectively. Ten of the patients with chiasmatic tumors and none with chiasmatic/hypothalamic tumors had neurofibromatosis I. Thirteen of the 14 chiasmatic tumors were managed with observation only, and none had progression requiring active intervention. For the chiasmatic/hypothalamic tumors, eight patients had subtotal resections (>95% resection), six had partial resections (50-95%), three had limited resections (<50%), and one had no surgery. There were fewer complications associated with the limited resections, especially with respect to hypothalamic dysfunction. There was no correlation between the extent of resection (subtotal, partial, or limited) and the time to tumor progression (average 18 months)., Conclusions: In conclusion, chiasmatic and chiasmatic/hypothalamic tumors are different entities, which should be separated out for the purposes of any study. For the chiasmatic/hypothalamic tumors, there was more morbidity and no prolongation of time to progression when radical resections were compared to more limited resections. Therefore, if surgery is performed, it may be appropriate to do a surgical procedure that strives only to provide a tissue diagnosis and to decompress the optic apparatus and/or ventricular system.
- Published
- 2002
3. Surgical implications of cerebral dysgenesis.
- Author
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Cochrane DD, Poskitt KJ, and Norman MG
- Subjects
- Brain growth & development, Facial Bones abnormalities, Facial Bones surgery, Humans, Skull abnormalities, Skull surgery, Brain abnormalities, Brain Diseases surgery
- Abstract
Cerebral dysgenesis encompasses varied disorders of brain development. Based on the understanding of these conditions provided by histopathologists, embryologists, radiologists and developmental pediatricians, surgeons are able to appropriately assist in the care of these patients. The surgeon can offer assessment of the ventriculomegaly that commonly accompanies cerebral dysgenesis in addition to providing methods to control hydrocephalus, to reconstruct cranial and facial malformations and to remove dysfunctional tissue. For most patients, surgical intervention is only one of the many factors that determine developmental prognosis. Based on the foundation built by other specialists, this review discusses cerebral dysgenesis from the perspective of historical and current surgical interventions.
- Published
- 1991
- Full Text
- View/download PDF
4. Intrauterine hydrocephalus and ventriculomegaly: associated anomalies and fetal outcome.
- Author
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Cochrane DD, Myles ST, Nimrod C, Still DK, Sugarman RG, and Wittmann BK
- Subjects
- Adult, Cesarean Section, Drainage, Female, Follow-Up Studies, Humans, Hydrocephalus diagnosis, Hydrocephalus therapy, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Ultrasonography, Abnormalities, Multiple complications, Hydrocephalus complications
- Abstract
Advances in fetal diagnostic techniques have opened many areas to prenatal anatomical scrutiny. Intrauterine hydrocephalus and ventriculomegaly are conditions which are readily diagnosed. Fetal intervention has been undertaken in humans in order to minimize the craniofacial disfigurement and to maximize the growth potential of the brain. To justify such an approach, the significance of all anomalies should be recognized prior to treatment. The authors have reviewed 41 cases of hydrocephalus diagnosed in utero in order to define associated anomalies and patient outcome. 75% of our personal series and 72% of the reviewed literature cases had other anomalies of the central nervous system. Other system malformations, some of which proved fatal, were seen commonly. Prenatal diagnostic techniques did not always reveal these additional problems. The outcome of these pregnancies is not good. Approximately one third of these fetuses have survived to be treated postnatally and to be followed up clinically. Only 7.5% of this series were felt to have attained normal developmental milestones. The remainder of the survivors have various focal and/or global cerebral deficits.
- Published
- 1985
- Full Text
- View/download PDF
5. Clinical - radiological correlates in intracerebral hematomas due to aneurysmal rupture.
- Author
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Benoit BG, Cochrane DD, Durity F, Ferguson GG, Fewer D, Hunter KM, Khan MI, Mohr G, Watts AR, Weir BK, and Wheelock WB
- Subjects
- Cerebral Hemorrhage diagnostic imaging, Cerebral Hemorrhage pathology, Hematoma diagnostic imaging, Hematoma pathology, Humans, Tomography, X-Ray Computed, Cerebral Hemorrhage diagnosis, Hematoma diagnosis, Intracranial Aneurysm complications
- Abstract
In this series of intracerebral hematomas from aneurysmal rupture, gathered from several neurosurgical services, certain morphological features were studied in detail. Patients with very large hematomas tended to have poor neurological grades on admission to hospital and their immediate discharge outlook was correspondingly poor. Ruptured middle cerebral and pericallosal artery aneurysms were relatively common causes of intracerebral hematomas. Patients with temporal lobe hematoma did relatively well; those with parietal hematoma did poorly. The larger the hematoma the less chance there was of developing cerebral vasospasm but the more likely was pre-operative brain herniation. The survival was more closely linked to size and location of the hematoma than to the location of aneurysm or the degree of midline shift.
- Published
- 1982
- Full Text
- View/download PDF
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