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When a sample is obtained from a two-stage cluster sampling scheme with unequal selection probabilities the sample distribution can differ from that of the population and the sampling design can be informative. In this case making valid inference under generalized linear mixed models can be quite challenging. We propose a novel approach for parameter estimation using an EM algorithm based on the approximate predictive distribution of the random effect. In the approximate predictive distribution instead of using the intractable sample likelihood function we use a normal approximation of the sampling distribution of the profile pseudo maximum likelihood estimator of the random effects in the level-one model. Two limited simulation studies show that the proposed method using the normal approximation performs well for modest cluster sizes. The proposed method is applied to the real data arising from 2011 Private Education Expenditures Survey (PEES) in Korea. The Canadian Journal of Statistics 45: 479-497; 2017 © 2017 Statistical Society of Canada [ABSTRACT FROM AUTHOR]