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Your search keyword '"Hunger, Stephen P"' showing total 14 results
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14 results on '"Hunger, Stephen P"'

2. Toxicity associated with intensive postinduction therapy incorporating clofarabine in the very high‐risk stratum of patients with newly diagnosed high‐risk B‐lymphoblastic leukemia: A report from the Childrenʼs Oncology Group study AALL1131

Author

Salzer, Wanda L., Burke, Michael J., Devidas, Meenakshi, Chen, Si, Gore, Lia, Larsen, Eric C., Borowitz, Michael, Wood, Brent, Heerema, Nyla A., Carroll, Andrew J., Hilden, Joanne M., Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Carroll, William L., and Hunger, Stephen P.

Published
2018
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4. Sex‐based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group report

Author

Gupta, Sumit, primary, Teachey, David T., additional, Chen, Zhiguo, additional, Rabin, Karen R., additional, Dunsmore, Kimberly P., additional, Larsen, Eric C., additional, Maloney, Kelly W., additional, Mattano, Leonard A., additional, Winter, Stuart S., additional, Carroll, Andrew J., additional, Heerema, Nyla A., additional, Borowitz, Michael J., additional, Wood, Brent L., additional, Carroll, William L., additional, Raetz, Elizabeth A., additional, Winick, Naomi J., additional, Loh, Mignon L., additional, Hunger, Stephen P., additional, and Devidas, Meenakshi, additional

Published
2022
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11. Toxicity associated with intensive postinduction therapy incorporating clofarabine in the very high-risk stratum of patients with newly diagnosed high-risk B-lymphoblastic leukemia: A report from the Children's Oncology Group study AALL1131

Author

Salzer, Wanda L., primary, Burke, Michael J., additional, Devidas, Meenakshi, additional, Chen, Si, additional, Gore, Lia, additional, Larsen, Eric C., additional, Borowitz, Michael, additional, Wood, Brent, additional, Heerema, Nyla A., additional, Carroll, Andrew J., additional, Hilden, Joanne M., additional, Loh, Mignon L., additional, Raetz, Elizabeth A., additional, Winick, Naomi J., additional, Carroll, William L., additional, and Hunger, Stephen P., additional

Published
2017
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12. Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial

Author

Zheng, Daniel J., primary, Lu, Xiaomin, additional, Schore, Reuven J., additional, Balsamo, Lyn, additional, Devidas, Meenakshi, additional, Winick, Naomi J., additional, Raetz, Elizabeth A., additional, Loh, Mignon L., additional, Carroll, William L., additional, Sung, Lillian, additional, Hunger, Stephen P., additional, Angiolillo, Anne L., additional, and Kadan-Lottick, Nina S., additional

Published
2017
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13. L-asparaginase treatment in acute lymphoblastic leukemia

Author

Pieters, Rob, primary, Hunger, Stephen P., additional, Boos, Joachim, additional, Rizzari, Carmelo, additional, Silverman, Lewis, additional, Baruchel, Andre, additional, Goekbuget, Nicola, additional, Schrappe, Martin, additional, and Pui, Ching-Hon, additional

Published
2010
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14. Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.

Author

Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, and Horan JT

Subjects
Adolescent, Adult, Child, Child, Preschool, Clinical Trials as Topic, Disease-Free Survival, Female, Humans, Immunophenotyping methods, Infant, Leukemia, Biphenotypic, Acute pathology, Male, Pediatrics trends, World Health Organization, Young Adult, Hematopoietic Stem Cell Transplantation methods, Leukemia, Biphenotypic, Acute epidemiology, Leukemia, Biphenotypic, Acute therapy, Prognosis
Abstract

Background: Optimal chemotherapy for treating mixed-phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World Health Organization 2016 (WHO2016) classification., Methods: To assess the relative efficacy of chemotherapy types for treating pediatric MPAL, the Children's Oncology Group (COG) Acute Leukemia of Ambiguous Lineage Task Force assembled a retrospective cohort of centrally reviewed WHO2016 MPAL cases selected from banking studies for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Patients were not treated in COG trials; treatment and outcome data were captured separately. The findings were then integrated with the available, mixed literature to develop a prospective trial in pediatric MPAL., Results: The central review confirmed that 54 of 70 cases fulfilled WHO2016 criteria for MPAL. ALL induction regimens achieved remission in 72% of the cases (28 of 39), whereas AML regimens achieved remission in 69% (9 of 13). The 5-year event-free survival (EFS) and overall survival (OS) rates for the entire cohort were 72% ± 8% and 77% ± 7%, respectively. EFS and OS were 75% ± 13% and 84% ± 11%, respectively, for those receiving ALL chemotherapy alone without HSCT (n = 21)., Conclusions: The results of the COG MPAL cohort and a literature review suggest that ALL chemotherapy without HSCT may be the preferred initial therapy. A prospective trial within the COG is proposed to investigate this approach; AML chemotherapy and/or HSCT will be reserved for those with treatment failure as assessed by minimal residual disease. Embedded biology studies will provide further insight into MPAL genomics., (© 2019 American Cancer Society.)

Published
2020
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