1. Malignant lymphoma of mucosa-associated lymphoid tissue arising in the thymus of a patient with Sjogren's syndrome: a morphologic, phenotypic, and genotypic study
- Author
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Takagi, Norio, Nakamura, Shigo, Yamamoto, Kazuhito, Kunishima, Kazuo, Takagi, Iwao, Suyama, Motokazu, Shinoda, Masayuki, Sugiura, Takahiko, Oyama, Atsushi, Suzuki, Hisamitsu, Koshikawa, Takashi, Kontani, Keiichi, Ueda, Ryuzo, Takahashi, Toshitada, Ariyoshi, Yutaka, and Suchi, Taizan
- Subjects
Sjogren's syndrome -- Complications ,Lymphoproliferative disorders -- Physiological aspects ,Lymphomas -- Case studies ,Endocrine gland tumors -- Case studies ,Health - Abstract
A 59-year-old woman with Sjogren's syndrome had an anterior mediastinal tumor. The tumor had epithelium-lined thymic cysts. Histologically, centrocyte-like (CCL) cells were present as clusters intermingling with small lymphocytes and plasma cells, invaded the epithelium, and formed characteristic lymphoepithelial lesions; the tumor was identified as malignant lymphoma arising in mucosa-associated lymphoid tissue (MALT). Within the tumor, trapped Hassall's corpuscles were recognized. Immunohistochemical staining demonstrated monotypic cytoplasmic kappa light chains in a small portion of the CCL cells. Furthermore, Southern blot hybridization studies showed rearrangements of immunoglobulin heavy chain, immunoglobulin kappa light chain, and T-cell receptor beta genes. The findings are consistent with thymic low-grade B-cell MALT lymphoma. Cancer 1992; 69:1347-1355.
- Published
- 1992