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26 results on '"Srivastava, Deo Kumar"'

2. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long‐term consequences

Author

Chemaitilly, Wassim, primary, Li, Zhenghong, additional, Brinkman, Tara M., additional, Delaney, Angela, additional, Huang, Sujuan, additional, Bjornard, Kari L., additional, Lam, Catherine G., additional, Wilson, Carmen L., additional, Barnes, Nicole, additional, Clark, Karen L., additional, Krasin, Matthew J., additional, Metzger, Monika L., additional, Sheyn, Anthony, additional, Bishop, Michael W., additional, Sabin, Noah D., additional, Howell, Rebecca M., additional, Helmig, Sara, additional, Shulkin, Barry L., additional, Triplett, Brandon M., additional, Pui, Ching‐Hong, additional, Gajjar, Amar, additional, Srivastava, Deo Kumar, additional, Green, Daniel M., additional, Armstrong, Gregory T., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Ness, Kristen K., additional, Sklar, Charles A., additional, and Krull, Kevin R., additional

Published
2021
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5. Cardiac remodeling after anthracycline and radiotherapy exposure in adult survivors of childhood cancer: A report from the St Jude Lifetime Cohort Study

Author

Jefferies, John L., primary, Mazur, Wojciech M., additional, Howell, Carrie R., additional, Plana, Juan C., additional, Ness, Kirsten K., additional, Li, Zhenghong, additional, Joshi, Vijaya M., additional, Green, Daniel M., additional, Mulrooney, Daniel A., additional, Towbin, Jeffrey A., additional, Martinez, Hugo R., additional, Goldberg, Jason F., additional, Howell, Rebecca M., additional, Srivastava, Deo Kumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Armstrong, Gregory T., additional

Published
2021
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11. Prevalence and predictors of cancer‐related worry and associations with health behaviors in adult survivors of childhood cancer

Author

McDonnell, Glynnis A., primary, Brinkman, Tara M., additional, Wang, Mingjuan, additional, Gibson, Todd M., additional, Heathcote, Lauren C., additional, Ehrhardt, Matthew J., additional, Srivastava, Deo Kumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Alberts, Nicole M., additional

Published
2021
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14. Cardiac biomarkers and association with subsequent cardiomyopathy and mortality among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort

Author

Dixon, Stephanie B., primary, Howell, Carrie R., additional, Lu, Lu, additional, Plana, Juan C., additional, Joshi, Vijaya M., additional, Luepker, Russell V., additional, Durand, Jean B., additional, Ky, Bonnie, additional, Lenihan, Daniel J., additional, Jefferies, John L., additional, Green, Daniel M., additional, Ehrhardt, Matthew J., additional, Mulrooney, Daniel A., additional, Folse, Timothy E., additional, Partin, Robyn E., additional, Santucci, Aimee K., additional, Howell, Rebecca M., additional, Srivastava, Deo Kumar, additional, Hudson, Melissa M., additional, Robison, Leslie L., additional, Ness, Kirsten K., additional, and Armstrong, Gregory T., additional

Published
2020
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18. Social adjustment in adolescent survivors of pediatric central nervous system tumors: A report from the Childhood Cancer Survivor Study

Author

Schulte, Fiona, primary, Brinkman, Tara M., additional, Li, Chenghong, additional, Fay-McClymont, Taryn, additional, Srivastava, Deo Kumar, additional, Ness, Kirsten K., additional, Howell, Rebecca M., additional, Mueller, Sabine, additional, Wells, Elizabeth, additional, Strother, Douglas, additional, Lafay-Cousin, Lucie, additional, Leisenring, Wendy, additional, Robison, Leslie L., additional, Armstrong, Gregory T., additional, and Krull, Kevin R., additional

Published
2018
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19. Perceptions of future health and cancer risk in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Author

Gibson, Todd M., primary, Li, Chenghong, additional, Armstrong, Gregory T., additional, Srivastava, Deo Kumar, additional, Leisenring, Wendy M., additional, Mertens, Ann, additional, Brinkman, Tara M., additional, Diller, Lisa, additional, Nathan, Paul C., additional, Hudson, Melissa M., additional, and Robison, Leslie L., additional

Published
2018
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20. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma

Author

Ehrhardt, Matthew J., primary, Mulrooney, Daniel A., additional, Li, Chenghong, additional, Baassiri, Malek J., additional, Bjornard, Kari, additional, Sandlund, John T., additional, Brinkman, Tara M., additional, Huang, I-Chan, additional, Srivastava, Deo Kumar, additional, Ness, Kirsten K., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Krull, Kevin R., additional

Published
2017
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22. Patterns and predictors of clustered risky health behaviors among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Author

Lown, E. Anne, primary, Hijiya, Nobuko, additional, Zhang, Nan, additional, Srivastava, Deo Kumar, additional, Leisenring, Wendy M., additional, Nathan, Paul C., additional, Castellino, Sharon M., additional, Devine, Katie A., additional, Dilley, Kimberley, additional, Krull, Kevin R., additional, Oeffinger, Kevin C., additional, Hudson, Melissa M., additional, Armstrong, Gregory T., additional, Robison, Leslie L., additional, and Ness, Kirsten K., additional

Published
2016
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25. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long-term consequences.

Author

Chemaitilly W, Li Z, Brinkman TM, Delaney A, Huang S, Bjornard KL, Lam CG, Wilson CL, Barnes N, Clark KL, Krasin MJ, Metzger ML, Sheyn A, Bishop MW, Sabin ND, Howell RM, Helmig S, Shulkin BL, Triplett BM, Pui CH, Gajjar A, Srivastava DK, Green DM, Armstrong GT, Robison LL, Hudson MM, Ness KK, Sklar CA, and Krull KR

Subjects
Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Quality of Life, Retrospective Studies, Risk Factors, Cancer Survivors psychology, Hypothyroidism epidemiology, Leukemia, Myeloid, Acute complications
Abstract

Background: Data on primary hypothyroidism and its long-term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and its associations with physical, neurocognitive, and psychosocial outcomes., Methods: This was a retrospective study with a cross-sectional health outcome analysis of an established cohort comprising 2965 survivors of childhood cancer (52.8% male; median current age, 30.9 years, median time since cancer diagnosis, 22.3 years). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between primary hypothyroidism and cancer-related risk factors, cardiovascular disease risk factors, frailty, neurocognitive and QOL outcomes, social attainment, and subsequent thyroid carcinoma. Associations between serum free thyroxine and thyrotropin levels at assessment and health outcomes were explored., Results: The prevalence of primary hypothyroidism was 14.7% (95% CI, 13.5%-16.0%). It was more likely in females (OR, 1.06; 95% CI, 1.03-1.08), was less likely in non-Whites (OR, 0.96; 95% CI, 0.93-0.99), was associated with thyroid radiotherapy (higher risk at higher doses), and was more common if cancer was diagnosed at an age ≥ 15.0 years versus an age < 5 years (OR, 1.05; 95% CI, 1.01-1.09). Primary hypothyroidism was associated with frailty (OR, 1.54; 95% CI, 1.05-2.26), dyslipidemia (OR, 1.52; 95% CI, 1.14-2.04), impaired physical QOL (OR, 1.66; 95% CI, 1.12-2.48), and having health care insurance (OR, 1.51; 95% CI, 1.07-2.12)., Conclusions: Primary hypothyroidism is common in survivors and is associated with unfavorable physical health and QOL outcomes. The impact of thyroid hormone replacement practices on these outcomes should be investigated further., (© 2021 American Cancer Society.)

Published
2022
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26. Cardiac biomarkers and association with subsequent cardiomyopathy and mortality among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort.

Author

Dixon SB, Howell CR, Lu L, Plana JC, Joshi VM, Luepker RV, Durand JB, Ky B, Lenihan DJ, Jefferies JL, Green DM, Ehrhardt MJ, Mulrooney DA, Folse TE, Partin RE, Santucci AK, Howell RM, Srivastava DK, Hudson MM, Robison LL, Ness KK, and Armstrong GT

Subjects
Adult, Biomarkers blood, Cardiomyopathies blood, Cardiomyopathies mortality, Cardiotoxicity, Child, Cohort Studies, Female, Humans, Male, Proportional Hazards Models, Young Adult, Cancer Survivors, Cardiomyopathies diagnosis, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Troponin T blood
Abstract

Background: Survivors of childhood cancer exposed to cardiotoxic therapies are at significant cardiovascular risk. The utility of cardiac biomarkers for identifying the risk of future cardiomyopathy and mortality is unknown., Methods: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) were assessed in 1213 adults 10 or more years from a childhood cancer diagnosis; 786 were exposed to anthracycline chemotherapy and/or chest-directed radiation therapy (RT). NT-proBNP values above age- and sex-specific 97.5th percentiles were considered abnormal. Generalized linear models estimated cross-sectional associations between abnormal NT-proBNP and anthracycline or chest RT doses as risk ratios with 95% confidence intervals (CIs). A Poisson distribution estimated rates and a Cox proportional hazards model estimated hazard ratios (HRs) for future cardiac events and death., Results: At a median age of 35.5 years (interquartile range, 29.8-42.5 years), NT-proBNP and cTnT were abnormal in 22.5% and 0.4%, respectively. Exposure to chest RT and exposure to anthracycline chemotherapy were each associated with a dose-dependent increased risk for abnormal NT-proBNP (P for trend <.0001). Among exposed survivors with no history of Common Terminology Criteria for Adverse Events-graded cardiomyopathy and with normal systolic function, survivors with abnormal NT-proBNP had higher rates per 1000 person-years of cardiac mortality (2.93 vs 0.96; P < .0001) and future cardiomyopathy (32.10 vs 15.98; P < .0001) and an increased risk of future cardiomyopathy (HR, 2.28; 95% CI, 1.28-4.08) according to a multivariable assessment., Conclusions: Abnormal NT-proBNP values were prevalent and, among survivors who were exposed to cardiotoxic therapy but did not have a history of cardiomyopathy or current systolic dysfunction, identified those at increased risk for future cardiomyopathy. Further longitudinal studies are needed to confirm this novel finding., (© 2020 American Cancer Society.)

Published
2021
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