1. Abscopal effect of radiation on bone metastases of breast cancer: A case report
- Author
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Huang Jin-Jhih, Shyh-Yau Wang, Henry Wc Leung, and Agnes L.F. Chan
- Subjects
Ablation Techniques ,0301 basic medicine ,Cancer Research ,Thoracic spine ,Advanced breast ,medicine.medical_treatment ,Bone Neoplasms ,Breast Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Breast cancer ,Immunogenic tumor ,Biomarkers, Tumor ,Humans ,Medicine ,Breast ,Aged ,Pharmacology ,Bedside to Bench Report ,business.industry ,Carcinoma, Ductal, Breast ,Cancer ,Abscopal effect ,medicine.disease ,Radiation therapy ,Treatment Outcome ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,Molecular Medicine ,Female ,Dose Fractionation, Radiation ,Tomography, X-Ray Computed ,business - Abstract
The abscopal effect is defined as the clearance of distant tumors after applying localized irradiation to a particular tumor site. It has been proposed that a mechanism for the abscopal effect might be the activation of the immune system, which leads to immunogenic tumor cell death. Here, we describe a woman with advanced breast cancer that received modified ablative radiation therapy that targeted her primary breast tumor. She experienced an apparent regression of metastatic mass in the thoracic spine. This case supported the hypothesis that the abscopal effect might be attributable to an activation of the systemic immune response.
- Published
- 2017