1. In situ memory T cells and patterns of invasion predict outcome in patients with early-stage oral squamous cell carcinoma.
- Author
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Shan Wang, Jiankai Xu, Yan Meng, Dongxia Qiang, Changsheng Sun, Lei Shi, and Eryang Zhao
- Subjects
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T cells , *SQUAMOUS cell carcinoma , *ORAL cancer diagnosis , *KAPLAN-Meier estimator ,HEALTH of patients - Abstract
PURPOSE: The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC). METHODS: One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC. Overall survival (OS) curves were calculated using the Kaplan-Meier method. RESULTS: Margin status was significantly associated with local recurrence in early stage OSCC (p = 0.000), and depth of invasion was also associated with regional recurrence (2 mm: p = 0.034; 4 mm: p = 0.015). The expression of CD45RO (p = 0.021) and POI (p = 0.027) individually was associated with OS, and patients in the group with combination score tended to have worse OS (p = 0.012). CONCLUSION: Combined evaluation of POI and CD45RO might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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