1. Association between cervical dysplasia and human papillomavirus in HIV seropositive women from Johannesburg South Africa
- Author
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Bruce Allan, Allen C Rinas, Audrey Pettifor, Anna-Lise Williamson, Hoa Van Le, Ian Sanne, Sophia Williams, Simon A. Levin, Pam Michelow, David A. Lewis, Jennifer S. Smith, Cynthia Firnhaber, and Doreen Schulze
- Subjects
Adult ,Human papillomavirus ,Cancer Research ,medicine.medical_specialty ,Health Status ,Population ,Comorbidity ,Cervical intraepithelial neoplasia ,Cervical dysplasia ,South Africa ,Young Adult ,Risk Factors ,Uterine Cervical Dysplasia ,HIV Seropositivity ,Epidemiology ,Prevalence ,Humans ,Medicine ,Young adult ,education ,Cervix ,Gynecology ,Original Paper ,Human papillomavirus 16 ,education.field_of_study ,Human papillomavirus 18 ,business.industry ,Obstetrics ,Papillomavirus Infections ,HPV infection ,HIV ,virus diseases ,Middle Aged ,medicine.disease ,CD4 Lymphocyte Count ,Cross-Sectional Studies ,medicine.anatomical_structure ,Oncology ,Dysplasia ,Women's Health ,Female ,business ,Precancerous Conditions - Abstract
Objective To examine the association between CD4 counts, HPV infection and the risk of cervical neoplasia among HIV-seropositive women. Methods A cross-sectional observational study was conducted among 1,010 HIV-seropositive women using cytology-based Pap smears. HPV DNA testing using Linear Array genotyping assay (Roche) was carried out in a subset of 191 patients. Multivariable-adjusted prevalence ratios (mPR) and 95% confidence intervals (CIs) were estimated with log-binomial regression. Results Among 1,010 HIV-seropositive women, the prevalence of AGC/ASCUS, LSIL and HSIL or greater was 8.3, 23.5 and 18.0%, respectively. The risk of cervical lesions was higher with CD4 500/mm3. HPV types 16 (41.7%) and HPV 56 (22.2%) were the most common types in HSIL cases. Women with CD4 levels
- Published
- 2009
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