1. Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women’s Health Initiative Observational Study
- Author
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Trabert, Britton, Coburn, Sally B, Falk, Roni T, Manson, JoAnn E, Brinton, Louise A, Gass, Margery L, Kuller, Lewis H, Rohan, Thomas E, Pfeiffer, Ruth M, Qi, Lihong, Stefanick, Marcia L, Wentzensen, Nicolas, Anderson, Garnet L, and Xu, Xia
- Subjects
Biomedical and Clinical Sciences ,Health Services and Systems ,Health Sciences ,Oncology and Carcinogenesis ,Reproductive Medicine ,Aging ,Cancer ,Rare Diseases ,Estrogen ,Prevention ,Clinical Research ,Ovarian Cancer ,Uterine Cancer ,Aged ,Endometrial Neoplasms ,Estradiol ,Estrogens ,Female ,Hormone Replacement Therapy ,Humans ,Middle Aged ,Ovarian Neoplasms ,Postmenopause ,Risk ,Endogenous estrogens ,Estrogen metabolites ,Ovarian cancer ,Endometrial cancer ,Nested case-control study ,Current hormone therapy users ,Nested case–control study ,Public Health and Health Services ,Epidemiology ,Oncology and carcinogenesis - Abstract
PurposeMenopausal hormone therapy (MHT) use induces alterations in circulating estrogens/estrogen metabolites, which may contribute to the altered risk of reproductive tract cancers among current users. Thus, the current study assessed associations between circulating estrogens/estrogen metabolites and ovarian and endometrial cancer risk among MHT users.MethodsWe conducted a nested case-control study among postmenopausal women using MHT at baseline in the Women's Health Initiative Observational Study (179 ovarian cancers, 396 controls; 230 endometrial cancers, 253 controls). Multivariable logistic regression was utilized to estimate odds ratios and 95% confidence intervals overall and by subtype.ResultsEstrogen/estrogen metabolite levels were not associated with overall or serous ovarian cancer risk, examined separately. However, unconjugated estradiol was positively associated with non-serous ovarian cancer risk [quintile 5 vs. quintile 1: 3.01 (1.17-7.73); p-trend = 0.03; p-het
- Published
- 2019