1. Immune cell triads reprogram exhausted CD8 + T cells for effective tumor elimination.
- Author
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Lise V, Malenica I, Roychoudhuri R, and Lugli E
- Subjects
- Humans, Immunotherapy methods, Animals, CD4-Positive T-Lymphocytes immunology, Antigen-Presenting Cells immunology, Mice, CD8-Positive T-Lymphocytes immunology, Neoplasms immunology, Neoplasms therapy
- Abstract
In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4
+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors., Competing Interests: Declaration of interests E.L. received research grants from Bristol Myers Squibb on a topic unrelated to this paper, royalties from the NIH for a patent on methods to develop T memory stem cells, and consulting fees from BD Biosciences, Biolegend, Swarm Therapeutics, Menarini, Amgen, and Pfizer., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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