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1. Tail Wags Dog: Primary Cilia and Tumorigenesis

Author

Barakat, Monique T. and Scott, Matthew P.

Subjects
*CANCER treatment, *LABORATORY dogs, *CARCINOGENESIS, *CELLULAR signal transduction, *CANCER genetics
Abstract

Aberrant activation of the Hedgehog (Hh) signaling pathway contributes to many forms of cancer. Primary cilia are Hh signal transduction centers. Two papers in a recent issue of Nature Medicine () show that mutating cilia can increase or reduce the rates of tumorigenesis depending on how the Hh pathway is disrupted. [Copyright &y& Elsevier]

Published
2009
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