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1. PARsing the Phrase “All in for Axin”— Wnt Pathway Targets in Cancer

Author

Fearon, Eric R.

Subjects
*CELLULAR signal transduction, *GENE targeting, *PROTEINS, *GENETIC transcription, *GENETIC regulation, *ADP-ribosylation, *CANCER treatment
Abstract

Genetic alternations resulting in constitutive stabilization of β-catenin and altered transcription of β-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/β-catenin pathway and suggests that compounds targeting tankyrase''s poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy. [Copyright &y& Elsevier]

Published
2009
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