1. Mitochondrial control of antigen presentation in cancer cells.
- Author
-
Soler-Agesta R, Anel A, and Galluzzi L
- Subjects
- Humans, T-Lymphocytes, Cytotoxic, Histocompatibility Antigens Class I, Antigen Presentation, Neoplasms genetics
- Abstract
Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism., Competing Interests: Declaration of interests L.G. is/has been holding research contracts with Lytix Biopharma, Promontory, and Onxeo; has received consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, Imvax, Sotio, Promontory, Noxopharm, EduCom, and the Luke Heller TECPR2 Foundation; and holds Promontory stock options. All other authors have no conflicts to declare., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF