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4 results on '"Lee, Lilian"'

1. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

Author

Dolma, Sonam, primary, Selvadurai, Hayden J., additional, Lan, Xiaoyang, additional, Lee, Lilian, additional, Kushida, Michelle, additional, Voisin, Veronique, additional, Whetstone, Heather, additional, So, Milly, additional, Aviv, Tzvi, additional, Park, Nicole, additional, Zhu, Xueming, additional, Xu, ChangJiang, additional, Head, Renee, additional, Rowland, Katherine J., additional, Bernstein, Mark, additional, Clarke, Ian D., additional, Bader, Gary, additional, Harrington, Lea, additional, Brumell, John H., additional, Tyers, Mike, additional, and Dirks, Peter B., additional

Published
2016
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2. MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin

Author

Gallo, Marco, primary, Coutinho, Fiona J., additional, Vanner, Robert J., additional, Gayden, Tenzin, additional, Mack, Stephen C., additional, Murison, Alex, additional, Remke, Marc, additional, Li, Ren, additional, Takayama, Naoya, additional, Desai, Kinjal, additional, Lee, Lilian, additional, Lan, Xiaoyang, additional, Park, Nicole I., additional, Barsyte-Lovejoy, Dalia, additional, Smil, David, additional, Sturm, Dominik, additional, Kushida, Michelle M., additional, Head, Renee, additional, Cusimano, Michael D., additional, Bernstein, Mark, additional, Clarke, Ian D., additional, Dick, John E., additional, Pfister, Stefan M., additional, Rich, Jeremy N., additional, Arrowsmith, Cheryl H., additional, Taylor, Michael D., additional, Jabado, Nada, additional, Bazett-Jones, David P., additional, Lupien, Mathieu, additional, and Dirks, Peter B., additional

Published
2015
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3. Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

Author

Vanner, Robert J., primary, Remke, Marc, additional, Gallo, Marco, additional, Selvadurai, Hayden J., additional, Coutinho, Fiona, additional, Lee, Lilian, additional, Kushida, Michelle, additional, Head, Renee, additional, Morrissy, Sorana, additional, Zhu, Xueming, additional, Aviv, Tzvi, additional, Voisin, Veronique, additional, Clarke, Ian D., additional, Li, Yisu, additional, Mungall, Andrew J., additional, Moore, Richard A., additional, Ma, Yussanne, additional, Jones, Steven J.M., additional, Marra, Marco A., additional, Malkin, David, additional, Northcott, Paul A., additional, Kool, Marcel, additional, Pfister, Stefan M., additional, Bader, Gary, additional, Hochedlinger, Konrad, additional, Korshunov, Andrey, additional, Taylor, Michael D., additional, and Dirks, Peter B., additional

Published
2014
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4. Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma.

Author

Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Xueming Zhu, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J. M., Marra, Marco A., and Malkin, David

Subjects
*MEDULLOBLASTOMA, *HEDGEHOG signaling proteins, *CANCER chemotherapy, *TUMOR growth, *CANCER treatment, *CANCER relapse, *ONCOLOGY
Abstract

Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. Rare Sox2+ cells produce rapidly cycling doublecortin+ progenitors that, together with their postmitotic progeny expressing NeuN, comprise tumor bulk. Sox2+ cells are enriched following anti-mitotic chemotherapy and Smoothened inhibition, creating a reservoir for tumor regrowth. Lineage traces from Sox2+ cells increase following treatment, suggesting that this population is responsible for relapse. Targeting Sox2+ cells with the antineoplastic mithramycin abrogated tumor growth. Addressing functional heterogeneity and eliminating Sox2+ cells presents a promising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma. [ABSTRACT FROM AUTHOR]

Published
2014
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