1. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
- Author
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Piotr Religa, Stina Garvin, Toshio Ohhashi, Steen Dissing, Meit A. Björndahl, Fumitaka Ikomi, Steve Clasper, Dagmar Galter, Björn Meister, Renhai Cao, Yihai Cao, David A. Jackson, and Katerina Tritsaris
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Cancer Research ,Platelet-derived growth factor ,Angiogenesis ,government.form_of_government ,Becaplermin ,Metastasis ,Cell Line ,Lymphatic System ,chemistry.chemical_compound ,Mice ,Neoplasms ,Medicine ,Animals ,Humans ,Receptors, Platelet-Derived Growth Factor ,Lymphangiogenesis ,Platelet-Derived Growth Factor ,business.industry ,Chemotaxis ,Organ Size ,Proto-Oncogene Proteins c-sis ,Cell Biology ,medicine.disease ,Mice, Inbred C57BL ,Lymphatic Endothelium ,Vascular endothelial growth factor A ,Lymphatic system ,Receptors, Vascular Endothelial Growth Factor ,chemistry ,Vascular endothelial growth factor C ,Oncology ,Lymphatic Metastasis ,Immunology ,Cancer research ,government ,Female ,business ,Cell Division ,Signal Transduction - Abstract
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis.
- Published
- 2006
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