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Competing Interests: Declaration of Interests Y.O. reports personal fees from Novartis, BMS, Lilly, Eisai, Chugai, Taiho, Alagan, Ono Pharmaceutical, Kyowa Kirin, and Pfizer outside the submitted work. J.M. reports personal fees from TORAY outside the submitted work. A.K. reports personal fees from Artnature Inc. and JTB Benefit Service Inc. outside the submitted work. K.O. reports personal fees from Daiichi-Sankyo, AstraZeneca, Ono Pharmaceutical, and Takeda Pharmaceutical outside the submitted work. T.T. reports grants and personal fees from Daiichi-Sankyo, grants and personal fees from Chugai, grants and personal fees from Kyowa Kirin, grants and personal fees from Eisai, grants from Ono Pharmaceutical, grants from BMS, grants from MSD, grants from Merck Serono, grants from Taiho, grants from Novartis, personal fees from Pfizer, personal fees from Eli Lilly, and personal fees from Celltrion Healthcare outside the submitted work. T.U. reports personal fees from Chugai, grants and personal fees from Eisai, personal fees from AstraZeneca, personal fees from Taiho, and personal fees from Novartis outside the submitted work. S.O. reports personal fees from Chugai, grants and personal fees from Eisai, grants and personal fees from Taiho, personal fees from AstraZeneca, personal fees from Pfizer, personal fees from Eli Lilly, personal fees from Kyowa Kirin, and personal fees from Nippon Kayaku outside the submitted work.