Search

Your search keyword '"Rodig, Scott"' showing total 11 results
Start Over Author "Rodig, Scott" Journal cancer cell
11 results on '"Rodig, Scott"'

2. Integrative Analysis Reveals an Outcome-Associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B Cell Lymphoma

Author

Monti, Stefano, Chapuy, Bjoern, Takeyama, Kunihiko, Rodig, Scott J., Hao, Yansheng, Yeda, Kelly T., Inguilizian, Haig, Mermel, Craig, Currie, Treeve, Dogan, Ahmet, Kutok, Jeffery L., Beroukhim, Rameen, Neuberg, Donna, Habermann, Thomas M., Getz, Gad, Kung, Andrew L., Golub, Todd R., and Shipp, Margaret A.

Published
2012
Full Text
View/download PDF

4. The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

Author

Berry, Teeara, Luther, William, Bhatnagar, Namrata, Jamin, Yann, Poon, Evon, Sanda, Takaomi, Pei, Desheng, Sharma, Bandana, Vetharoy, Winston R., Hallsworth, Albert, Ahmad, Zai, Barker, Karen, Moreau, Lisa, Webber, Hannah, Wang, Wenchao, Liu, Qingsong, Perez-Atayde, Antonio, Rodig, Scott, Cheung, Nai-Kong, Raynaud, Florence, Hallberg, Bengt, Robinson, Simon P., Gray, Nathanael S., Pearson, Andrew D.J., Eccles, Suzanne A., Chesler, Louis, and George, Rani E.

Published
2012
Full Text
View/download PDF

7. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

Author

Dangaj, Denarda, primary, Bruand, Marine, additional, Grimm, Alizée J., additional, Ronet, Catherine, additional, Barras, David, additional, Duttagupta, Priyanka A., additional, Lanitis, Evripidis, additional, Duraiswamy, Jaikumar, additional, Tanyi, Janos L., additional, Benencia, Fabian, additional, Conejo-Garcia, Jose, additional, Ramay, Hena R., additional, Montone, Kathleen T., additional, Powell, Daniel J., additional, Gimotty, Phyllis A., additional, Facciabene, Andrea, additional, Jackson, Donald G., additional, Weber, Jeffrey S., additional, Rodig, Scott J., additional, Hodi, Stephen F., additional, Kandalaft, Lana E., additional, Irving, Melita, additional, Zhang, Lin, additional, Foukas, Periklis, additional, Rusakiewicz, Sylvie, additional, Delorenzi, Mauro, additional, and Coukos, George, additional

Published
2019
Full Text
View/download PDF

8. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

Author

Wu, Shuo-Chieh, primary, Li, Loretta S., additional, Kopp, Nadja, additional, Montero, Joan, additional, Chapuy, Bjoern, additional, Yoda, Akinori, additional, Christie, Amanda L., additional, Liu, Huiyun, additional, Christodoulou, Alexandra, additional, van Bodegom, Diederik, additional, van der Zwet, Jordy, additional, Layer, Jacob V., additional, Tivey, Trevor, additional, Lane, Andrew A., additional, Ryan, Jeremy A., additional, Ng, Samuel Y., additional, DeAngelo, Daniel J., additional, Stone, Richard M., additional, Steensma, David, additional, Wadleigh, Martha, additional, Harris, Marian, additional, Mandon, Emeline, additional, Ebel, Nicolas, additional, Andraos, Rita, additional, Romanet, Vincent, additional, Dölemeyer, Arno, additional, Sterker, Dario, additional, Zender, Michael, additional, Rodig, Scott J., additional, Murakami, Masato, additional, Hofmann, Francesco, additional, Kuo, Frank, additional, Eck, Michael J., additional, Silverman, Lewis B., additional, Sallan, Stephen E., additional, Letai, Anthony, additional, Baffert, Fabienne, additional, Vangrevelinghe, Eric, additional, Radimerski, Thomas, additional, Gaul, Christoph, additional, and Weinstock, David M., additional

Published
2015
Full Text
View/download PDF

9. Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Author

Chapuy, Bjoern, primary, McKeown, Michael R., additional, Lin, Charles Y., additional, Monti, Stefano, additional, Roemer, Margaretha G.M., additional, Qi, Jun, additional, Rahl, Peter B., additional, Sun, Heather H., additional, Yeda, Kelly T., additional, Doench, John G., additional, Reichert, Elaine, additional, Kung, Andrew L., additional, Rodig, Scott J., additional, Young, Richard A., additional, Shipp, Margaret A., additional, and Bradner, James E., additional

Published
2014
Full Text
View/download PDF

10. Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Author

Chapuy, Bjoern, primary, McKeown, Michael R., additional, Lin, Charles Y., additional, Monti, Stefano, additional, Roemer, Margaretha G.M., additional, Qi, Jun, additional, Rahl, Peter B., additional, Sun, Heather H., additional, Yeda, Kelly T., additional, Doench, John G., additional, Reichert, Elaine, additional, Kung, Andrew L., additional, Rodig, Scott J., additional, Young, Richard A., additional, Shipp, Margaret A., additional, and Bradner, James E., additional

Published
2013
Full Text
View/download PDF

11. The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

Author

Berry, Teeara, Luther, William, Bhatnagar, Namrata, Jamin, Yann, Poon, Evon, Sanda, Takaomi, Pei, Desheng, Sharma, Bandana, Vetharoy, Winston R., Hallsworth, Albert, Ahmad, Zai, Barker, Karen, Moreau, Lisa, Webber, Hannah, Wang, Wenchao, Liu, Qingsong, Perez-Atayde, Antonio, Rodig, Scott, Cheung, Nai-Kong, and Raynaud, Florence

Subjects
*GENETIC mutation, *CARCINOGENESIS, *NEUROBLASTOMA, *PROTEIN-tyrosine kinase inhibitors, *GENE expression, *LABORATORY mice
Abstract

Summary: The ALKF1174L mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALKF1174L in the neural crest. Compared to ALKF1174L and MYCN alone, co-expression of these two oncogenes led to the development of neuroblastomas with earlier onset, higher penetrance, and enhanced lethality. ALKF1174L/MYCN tumors exhibited increased MYCN dosage due to ALKF1174L-induced activation of the PI3K/AKT/mTOR and MAPK pathways, coupled with suppression of MYCN pro-apoptotic effects. Combined treatment with the ATP-competitive mTOR inhibitor Torin2 overcame the resistance of ALKF1174L/MYCN tumors to crizotinib. Our findings demonstrate a pathogenic role for ALKF1174L in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma. [Copyright &y& Elsevier]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results