1. The effective function of circular RNA in colorectal cancer
- Author
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Maziar Ashrafian Bonab, Mandana Ameli-Mojarad, Hosna Babini, Christopher N. J. Young, Ehsan Nazemalhosseini-Mojarad, Melika Ameli-Mojarad, Mahrooyeh Hadizadeh, and Ashrafian Bonab, Maziar
- Subjects
Cancer Research ,Colorectal cancer ,Review ,Noncoding RNA ,Metastasis ,Circular RNA ,microRNA ,Genetics ,medicine ,RC254-282 ,sub_chemistry ,sub_healthsciences ,QH573-671 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer ,medicine.disease ,Non-coding RNA ,Long non-coding RNA ,Oncology ,RNA splicing ,Cancer research ,Cytology ,sub_biomedicalsciences - Abstract
Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC.
- Published
- 2021
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