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Your search keyword '"Fiorentino, Michelangelo"' showing total 13 results
Start Over Author "Fiorentino, Michelangelo" Journal cancer epidemiology, biomarkers & prevention
13 results on '"Fiorentino, Michelangelo"'

1. A Prospective Study of Intraprostatic Inflammation, Focal Atrophy, and Progression to Lethal Prostate Cancer

Author

Zhang, Yiwen, primary, Zhou, Cindy Ke, additional, Rencsok, Emily M., additional, Fall, Katja, additional, Lotan, Tamara L., additional, Loda, Massimo, additional, Giunchi, Francesca, additional, Platz, Elizabeth A., additional, De Marzo, Angelo M., additional, Mucci, Lorelei A., additional, Fiorentino, Michelangelo, additional, and Ebot, Ericka M., additional

Published
2019
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2. Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer.

Author

Pernar, Claire H., Parmigiani, Giovanni, Giovannucci, Edward L., Rimm, Eric B., Tyekucheva, Svitlana, Loda, Massimo, Finn, Stephen P., Heiden, Matthew G. Vander, Fiorentino, Michelangelo, Ebot, Ericka M., and Mucci, Lorelei A.

Abstract

Background: Men engaged in high physical activity have lower risks of advanced and fatal prostate cancer. Mechanisms underlying this association are not well understood but may include systemic and tumor-specific effects. We investigated potential mechanisms linking physical activity and gene expression in prostate tissue from men with prostate cancer. Methods: We included a subset of 118 men in the Health Professionals Follow-up Study diagnosed with prostate cancer between 1986 and 2005 with whole-transcriptome gene expression profiling on tumor and adjacent normal prostate tissue and physical activity data. Long-term vigorous physical activity was self-reported as the average time spent engaged in various forms of recreational physical activity at baseline and biennially until prostate cancer diagnosis. Gene set enrichment analysis was performed among KEGG and Hallmark gene sets to identify pathways with differential expression based on vigorous physical activity. Results: In adjacent normal tissue, we identified 25 KEGG gene sets enriched (downregulated) in the highest compared with lowest quintile of vigorous physical activity at an FDR <0.10, including a number of cancer- and immune-related pathways. Although no gene sets reached statistical significance in tumor tissue, top gene sets differentially expressed included TGF beta, apoptosis, and p53 signaling pathways. Conclusions: These findings suggest that physical activity may influence the tumor microenvironment. Future studies are needed to confirm these findings and further investigate potential mechanisms linking physical activity to lethal prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2021
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3. A Prospective Study of Intraprostatic Inflammation, Focal Atrophy, and Progression to Lethal Prostate Cancer.

Author

Yiwen Zhang, Ke Zhou, Cindy, Rencsok, Emily M., Fall, Katja, Lotan, Tamara L., Loda, Massimo, Giunchi, Francesca, Platz, Elizabeth A., De Marzo, Angelo M., Mucci, Lorelei A., Fiorentino, Michelangelo, and Ebot, Ericka M.

Abstract

Background: Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance. Methods: In the Health Professionals Follow-Up Study and Physicians' Health Study, we studied 1,035 men diagnosed with prostate cancer. A genitourinary pathologist centrally reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and four subtypes of focal atrophy. Cox proportional hazards models adjusted for potential confounders were used to estimate HRs and 95% confidence intervals (CI) for the association of these features with lethal prostate cancer, defined as development of metastatic disease or death during follow-up. Results: During a median of 12 years of follow-up, 153 men developed lethal prostate cancer. A total of 84% of men had histologic evidence of chronic inflammation and 30% had acute inflammation. Both chronic and acute inflammation were inversely associated with lethal prostate cancer in age- and lifestyle-adjusted models. Chronic inflammation remained inversely associated with lethal prostate cancer after additionally adjusting for prognostic clinical features (HR = 0.45; 95% CI, 0.30-0.69 for mild and HR = 0.51; 95% CI, 0.33-0.80 for moderate to severe). None of the atrophic lesions were associated with lethal prostate cancer. Conclusions: Our data suggest that the presence of inflammation, particularly chronic inflammation, in prostate cancer tissue is associated with better prognosis among patients with prostate cancer. Impact: This is the largest prospective cohort study to examine the association between inflammation, focal atrophy, and lethal prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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4. Height, Obesity, and the Risk of TMPRSS2:ERG-Defined Prostate Cancer

Author

Graff, Rebecca E., primary, Ahearn, Thomas U., additional, Pettersson, Andreas, additional, Ebot, Ericka M., additional, Gerke, Travis, additional, Penney, Kathryn L., additional, Wilson, Kathryn M., additional, Markt, Sarah C., additional, Pernar, Claire H., additional, Gonzalez-Feliciano, Amparo G., additional, Song, Mingyang, additional, Lis, Rosina T., additional, Schmidt, Daniel R., additional, Vander Heiden, Matthew G., additional, Fiorentino, Michelangelo, additional, Giovannucci, Edward L., additional, Loda, Massimo, additional, and Mucci, Lorelei A., additional

Published
2018
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5. Perineural Invasion and Risk of Lethal Prostate Cancer

Author

Zareba, Piotr, primary, Flavin, Richard, additional, Isikbay, Masis, additional, Rider, Jennifer R., additional, Gerke, Travis A., additional, Finn, Stephen, additional, Pettersson, Andreas, additional, Giunchi, Francesca, additional, Unger, Robert H., additional, Tinianow, Alex M., additional, Andersson, Swen-Olof, additional, Andrén, Ove, additional, Fall, Katja, additional, Fiorentino, Michelangelo, additional, and Mucci, Lorelei A., additional

Published
2017
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6. Prostate-Specific Membrane Antigen Protein Expression in Tumor Tissue and Risk of Lethal Prostate Cancer

Author

Kasperzyk, Julie L., primary, Finn, Stephen P., additional, Flavin, Richard, additional, Fiorentino, Michelangelo, additional, Lis, Rosina, additional, Hendrickson, Whitney K., additional, Clinton, Steven K., additional, Sesso, Howard D., additional, Giovannucci, Edward L., additional, Stampfer, Meir J., additional, Loda, Massimo, additional, and Mucci, Lorelei A., additional

Published
2013
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7. Protein Expression of PTEN, Insulin-Like Growth Factor I Receptor (IGF-IR), and Lethal Prostate Cancer: A Prospective Study

Author

Zu, Ke, primary, Martin, Neil E., additional, Fiorentino, Michelangelo, additional, Flavin, Richard, additional, Lis, Rosina T., additional, Sinnott, Jennifer A., additional, Finn, Stephen, additional, Penney, Kathryn L., additional, Ma, Jing, additional, Fazli, Ladan, additional, Gleave, Martin E., additional, Bismar, Tarek A., additional, Stampfer, Meir J., additional, Pollak, Michael N., additional, Loda, Massimo, additional, Mucci, Lorelei A., additional, and Giovannucci, Edward, additional

Published
2013
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8. The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis

Author

Pettersson, Andreas, primary, Graff, Rebecca E., additional, Bauer, Scott R., additional, Pitt, Michael J., additional, Lis, Rosina T., additional, Stack, Edward C., additional, Martin, Neil E., additional, Kunz, Lauren, additional, Penney, Kathryn L., additional, Ligon, Azra H., additional, Suppan, Catherine, additional, Flavin, Richard, additional, Sesso, Howard D., additional, Rider, Jennifer R., additional, Sweeney, Christopher, additional, Stampfer, Meir J., additional, Fiorentino, Michelangelo, additional, Kantoff, Philip W., additional, Sanda, Martin G., additional, Giovannucci, Edward L., additional, Ding, Eric L., additional, Loda, Massimo, additional, and Mucci, Lorelei A., additional

Published
2012
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9. Common Polymorphisms in the Adiponectin and Its Receptor Genes, Adiponectin Levels and the Risk of Prostate Cancer

Author

Dhillon, Preet K., primary, Penney, Kathryn L., additional, Schumacher, Fredrick, additional, Rider, Jennifer R., additional, Sesso, Howard D., additional, Pollak, Michael, additional, Fiorentino, Michelangelo, additional, Finn, Stephen, additional, Loda, Massimo, additional, Rifai, Nader, additional, Mucci, Lorelei A., additional, Giovannucci, Edward, additional, Stampfer, Meir J., additional, and Ma, Jing, additional

Published
2011
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11. Aberrant Cytoplasmic Expression of p63 and Prostate Cancer Mortality

Author

Dhillon, Preet K., primary, Barry, Marc, additional, Stampfer, Meir J., additional, Perner, Sven, additional, Fiorentino, Michelangelo, additional, Fornari, Alessandro, additional, Ma, Jing, additional, Fleet, Julia, additional, Kurth, Tobias, additional, Rubin, Mark A., additional, and Mucci, Lorelei A., additional

Published
2009
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12. Protein Expression of PTEN, Insulin-Like Growth Factor I Receptor (IGF-IR), and Lethal ProstateCancer: A Prospective Study.

Author

Ke Zu, Martin, Neil E., Fiorentino, Michelangelo, Flavin, Richard, Lis, Rosina T., Sinnott, Jennifer A., Finn, Stephen, Penney, Kathryn L., Jing Ma, Fazli, Ladan, Gleave, Martin E., Bismar, Tarek A., Stampfer, Meir J., Pollak, Michael N., Loda, Massimo, Mucci, Lorelei A., and Giovannucci, Edward

Abstract

The article presents a study that investigated the association between phosphatase and tensin homolog (PTEN) expression and prostate cancer mortality. The study explored the potential effect modification by IGF-IR, a direct activator of the phosphoinositide-3-kinase (PI3K) pathway, and evaluated protein expression in tumor using tumor tissues.

Published
2013
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13. Perineural Invasion and Risk of Lethal Prostate Cancer

Author

Swen Olof Andersson, Richard Flavin, Alex M. Tinianow, Lorelei A. Mucci, Francesca Giunchi, Katja Fall, Andreas Pettersson, Stephen P. Finn, Piotr Zareba, Michelangelo Fiorentino, Jennifer R. Rider, Masis Isikbay, Travis Gerke, Robert H Unger, Ove Andrén, Zareba, Piotr, Flavin, Richard, Isikbay, Masi, Rider, Jennifer R, Gerke, Travis A, Finn, Stephen, Pettersson, Andrea, Giunchi, Francesca, Unger, Robert H, Tinianow, Alex M, Andersson, Swen-Olof, Andrén, Ove, Fall, Katja, Fiorentino, Michelangelo, and Mucci, Lorelei A

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Epidemiology, medicine.medical_treatment, 030232 urology & nephrology, Perineural invasion, Article, Metastasis, Cohort Studies, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, medicine, Humans, Neoplasm Invasiveness, Peripheral Nerves, Aged, business.industry, Prostatectomy, Prostatic Neoplasms, Cancer, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Cohort, Neoplasm Grading, business, Watchful waiting, Cohort study
Abstract

Background: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate cancer has been associated with cancer aggressiveness. Methods: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting Cohort of 615 men who underwent watchful waiting, and the U.S. Health Professionals Follow-Up Study of 849 men treated with radical prostatectomy. One pathologist performed a standardized histopathologic review assessing PNI and Gleason grade. Patients were followed from diagnosis until metastasis or death. Results: The prevalence of PNI was 7% and 44% in the untreated and treated cohorts, respectively. PNI was more common in high Gleason grade tumors in both cohorts. PNI was associated with enhanced tumor angiogenesis, but not tumor proliferation or apoptosis. In the Swedish study, PNI was associated with lethal prostate cancer [OR 7.4; 95% confidence interval (CI), 3.6–16.6; P < 0.001]. A positive, although not statistically significant, association persisted after adjustment for age, Gleason grade, and tumor volume (OR 1.9; 95% CI, 0.8–5.1; P = 0.17). In the U.S. study, PNI predicted lethal prostate cancer independent of clinical factors (HR 1.8; 95% CI, 1.0, 3.3; P =0.04). Conclusions: These data support the hypothesis that perineural invasion creates a microenvironment that promotes cancer aggressiveness. Impact: Our findings suggest that PNI should be a standardized component of histopathologic review, and highlights a mechanism underlying prostate cancer metastasis. Cancer Epidemiol Biomarkers Prev; 26(5); 719–26. ©2017 AACR.

Published
2017

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