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Start Over Author "Pierce Jr., William M." Journal cancer epidemiology, biomarkers & prevention
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1. 2-Amino-3,8-Dimethylimidazo-[4,5-f]Quinoxaline-Induced DNA Adduct Formation and Mutagenesis in DNA Repair-Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P4501A1 and Rapid or Slow Acetylator N-Acetyltransferase 2.

Author

Bendaly, Jean, Shuang Zhao, Neale, Jason R., Metry, Kristin J., Doll, Mark A., States, J. Christopher, Pierce Jr., William M., and Hein, David W.

Abstract

The article discusses a study which assessed that 2-Amino-3,8-dimethylmidazo-[4,5-f]quinoxaline-induced DNA damage and subsequent mutagenesis would be faster than NAT2 acetylators using nucleotide excision repair-deficient Chinese hamster ovary cells expressing human alleles, p4501Aa1 and either NAT2*4 and NAT2*5B. Through the measurement of catalytic activity, transfection of human alleles were confirmed. High performance liquid chromatography was used to assay acetyltransferases.

Published
2007
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