1. Features of polycythemia vera in the 8p12 myeloproliferative syndrome
- Author
-
Welborn, Jeanna, Fenner, Shelly, and Parks, Robert
- Subjects
- *
MYELOPROLIFERATIVE neoplasms , *POLYCYTHEMIA vera , *CHROMOSOMAL translocation , *LEUCOCYTOSIS , *EOSINOPHILIA , *LYMPHOCYTE transformation , *T-cell lymphoma , *CYTOGENETICS , *GENETICS - Abstract
Abstract: The 8p12 myeloproliferative syndrome is a distinct myeloid disorder associated with a translocation involving chromosome region 8p12 (HUGO nomenclature). It is characterized by leukocytosis, eosinophilia, and a concurrent or rapid transformation to a T-cell lymphoblastic lymphoma. We report a case of polycythemia vera as a clinical presentation of the 8p12 myeloproliferative syndrome and review the literature. Atypical features in patients with polycythemia vera should be investigated with cytogenetic evaluation. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF