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Your search keyword '"Haruhiko Ninomiya"' showing total 2 results
Start Over Author "Haruhiko Ninomiya" Journal cancer genetics and cytogenetics
2 results on '"Haruhiko Ninomiya"'

1. Derivative (1;7)(q10;p10) in a patient with de novo acute erythroblastic leukemia (AML-M6)

Author

Haruhiko Ninomiya, Atsushi Shinagawa, Tsukasa Abe, Tsunehiko Komatsu, and Naoshi Obara

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Poor prognosis, medicine.medical_treatment, Chromosomal translocation, Bone Marrow Cells, Biology, Erythroblastic Leukemia, Translocation, Genetic, hemic and lymphatic diseases, Internal medicine, Genetics, medicine, Humans, Molecular Biology, Aged, Chromosome 7 (human), Chemotherapy, De novo acute, Cytogenetics, Myeloid leukemia, Lymphocyte Subsets, Chromosomes, Human, Pair 1, Karyotyping, Immunology, Leukemia, Erythroblastic, Acute, Chromosomes, Human, Pair 7
Abstract

A rare association of der(1;7)(q10;p10) with de novo acute erythroblastic leukemia (AML-M6) in a 63-year-old male is reported. While this unbalanced 1;7 translocation, der(1;7), has been reported often in therapy-related myelodysplastic syndrome (t-MDS) or therapy-related acute myeloid leukemia (t-AML), its associations with de novo AML-FAB-M6 have rarely been reported. Although der(1;7) has been reported as a cytogenetic factor for poor prognosis in t-MDS/AML, our patient showed a good response to chemotherapy and obtained complete remission, although longer observation is required to evaluate the prognosis.

Published
1999

2. Complex translocation (6;21;8), a variant of t(8;21), with trisomy 4 in a patient with acute myelogenous leukemia (M2)

Author

Haruhiko Ninomiya, Atsushi Shinagawa, and Tsunehiko Komatsu

Subjects
Adult, Cancer Research, Chromosomes, Human, Pair 21, Recombinant Fusion Proteins, Aneuploidy, Chromosomal translocation, Trisomy, Biology, Translocation, Genetic, Myelogenous, RUNX1 Translocation Partner 1 Protein, hemic and lymphatic diseases, Proto-Oncogene Proteins, Genetics, medicine, Humans, RNA, Messenger, neoplasms, Molecular Biology, Reverse Transcriptase Polymerase Chain Reaction, Chromosome Mapping, Genetic Variation, Karyotype, Gene rearrangement, medicine.disease, Molecular biology, Reverse transcriptase, Chromosome Banding, DNA-Binding Proteins, Leukemia, Leukemia, Myeloid, Acute, Karyotyping, Core Binding Factor Alpha 2 Subunit, Chromosomes, Human, Pair 6, Female, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 8, Transcription Factors
Abstract

The t(8;21)(q22;q22) is the second-most frequently observed nonrandom karyotypic abnormality associated with acute myelogenous leukemia (AML), especially in FAB M2. Trisomy 4 is also a specific chromosomal abnormality for AML FAB M2 or M4. We experienced a 37-year-old woman with a morphologically AML FAB M2 carrying a rare complex translocation (6;21;8)(p21;q22;q22) resulting in AML1 gene rearrangement. A subclone with an additional chromosomal abnormality, trisomy 4, was also revealed. Similarly to the typical t(8;21), a conventional chemotherapy successfully induced into complete remission associated with a recovery of normal karyotype, 46,XX, although AML1/MTG8 (ETO) chimera mRNA was detected by reverse transcriptase polymerase chain reaction.

Published
1999

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