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Start Over Author "Hernández-García, M T" Journal cancer genetics and cytogenetics
1 results on '"Hernández-García, M T"'

1. AML with unusual chromosomal changes. Translocation (15;21) and 5q- in the presence of two normal chromosomes 5.

Author

Carrasco Juan JL, Otero Gómez A, Garcia Miranda JL, Brito Barroso ML, Hernández García MT, and Hernández Nieto L

Subjects
Adult, Chromosomes, Human, Pair 5, Humans, Male, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 21, Leukemia, Myeloid, Acute genetics, Translocation, Genetic genetics
Abstract

We performed serial cytogenetic studies of the bone marrow (BM) of a patient with acute myeloblastic leukemia (AML) and noted abnormal karyotypes 47,XY,+del(5)(q12q34),t(15;21)(q21;q22)/47,XY,+del(5)(q12q34 ) during the second relapse. Although a case of this t(15;21) was recently observed in a female patient with acute nonlymphocytic leukemia (ANLL) of subtype M4 of the French-American-British (FAB) classification, the present article constitutes the first report of its occurrence in association with ANLL of subtype M1-M2. Furthermore, the presence of the 5q- accompanied by two chromosomes 5 of normal appearance is very rare and of great interest.

Published
1992
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