1. PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients.
- Author
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Sun S, Fei X, Mao Y, Wang X, Garfield DH, Huang O, Wang J, Yuan F, Sun L, Yu Q, Jin X, Wang J, and Shen K
- Subjects
- Adult, Aged, Aged, 80 and over, Apoptosis immunology, Breast Neoplasms mortality, Breast Neoplasms pathology, Breast Neoplasms radiotherapy, Breast Neoplasms surgery, CD8-Positive T-Lymphocytes chemistry, CD8-Positive T-Lymphocytes pathology, Carcinoma, Ductal, Breast mortality, Carcinoma, Ductal, Breast pathology, Carcinoma, Ductal, Breast radiotherapy, Carcinoma, Ductal, Breast surgery, Carcinoma, Lobular immunology, Carcinoma, Lobular mortality, Carcinoma, Lobular pathology, Carcinoma, Lobular radiotherapy, Carcinoma, Lobular surgery, Combined Modality Therapy, Disease-Free Survival, Female, Follow-Up Studies, Forkhead Transcription Factors analysis, Humans, Kaplan-Meier Estimate, Lymphocyte Count, Lymphocytes, Tumor-Infiltrating chemistry, Lymphocytes, Tumor-Infiltrating pathology, Mastectomy, Middle Aged, Prognosis, Radiotherapy, Adjuvant, Survival Analysis, T-Lymphocyte Subsets chemistry, T-Lymphocyte Subsets pathology, T-Lymphocytes, Cytotoxic chemistry, T-Lymphocytes, Cytotoxic pathology, T-Lymphocytes, Regulatory chemistry, T-Lymphocytes, Regulatory pathology, Antigens, Differentiation, T-Lymphocyte analysis, Breast Neoplasms immunology, CD8-Positive T-Lymphocytes immunology, Carcinoma, Ductal, Breast immunology, Lymphocytes, Tumor-Infiltrating immunology, Programmed Cell Death 1 Receptor analysis, T-Lymphocyte Subsets immunology, T-Lymphocytes, Cytotoxic immunology, T-Lymphocytes, Regulatory immunology
- Abstract
The programmed death-1 (PD-1) molecule is mainly expressed on functionally "exhausted" CD8(+) T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8(+) cytotoxic T lymphocytes, FOXP3(+) (Treg cell marker), and PD-1(+) immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1(+) immune cells and FOXP3(+) Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1(+) cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1(+) immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer.
- Published
- 2014
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